Placenta Accreta Spectrum Disorders: Knowledge Gaps in Anesthesia Care

Christine M. Warrick, John C. Markley, Michaela K. Farber, Mrinalini Balki, Daniel Katz, Philip E. Hess, Cesar Padilla, Jonathan H. Waters, Carolyn F. Weiniger, Alexander J. Butwick

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Placenta accreta spectrum (PAS) disorder is a potentially life-threatening condition that can occur during pregnancy. PAS puts pregnant individuals at a very high risk of major blood loss, hysterectomy, and intensive care unit admission. These patients should receive care in a center with multidisciplinary experience and expertise in managing PAS disorder. Obstetric anesthesiologists play vital roles in the peripartum care of pregnant patients with suspected PAS. As well as providing high-quality anesthesia care, obstetric anesthesiologists coordinate peridelivery care, drive transfusion-related decision making, and oversee postpartum analgesia. However, there are a number of key knowledge gaps related to the anesthesia care of these patients. For example, limited data are available describing optimal anesthesia staffing models for scheduled and unscheduled delivery. Evidence and consensus are lacking on the ideal surgical location for delivery; primary mode of anesthesia for cesarean delivery; preoperative blood ordering; use of pharmacological adjuncts for hemorrhage management, such as tranexamic acid and fibrinogen concentrate; neuraxial blocks and abdominal wall blocks for postoperative analgesia; and the preferred location for postpartum care. It is also unclear how anesthesia-related decision making and interventions impact physical and mental health outcomes. High-quality international multicenter studies are needed to fill these knowledge gaps and advance the anesthesia care of patients with PAS.

Original languageEnglish
Pages (from-to)191-197
Number of pages7
JournalAnesthesia and Analgesia
Issue number1
StatePublished - 1 Jul 2022


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