Pinocchio cells: morphologically atypical immunologically heterogeneous lymphocytes induced by treatment with interleukin 2

Paolo Alberto Paciucci; Pilar Garin Chesa; Maria Teresa Fierro; Ronald Gordon; Robert G. Konefal; Oliver Glidewell; James F. Holland

doi:10.1016/0165-2478(88)90161-7

Pinocchio cells: morphologically atypical immunologically heterogeneous lymphocytes induced by treatment with interleukin 2

Paolo Alberto Paciucci, Pilar Garin Chesa, Maria Teresa Fierro, Ronald Gordon, Robert G. Konefal, Oliver Glidewell, James F. Holland

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4 Scopus citations

Abstract

We describe a novel cell type, the Pinocchio cell, that appears in the peripheral blood of all patients receiving treatment with interleukin 2, up to 20000 cells/μl. This cell is characterized by a prominent and granular proboscis with which it attaches to tumor cells and mediates tumor cell lysis. Pinocchio cells are immunologically heterogeneous and express antigens of both T and NK cells; Pinocchio cells are adherent in culture and are more cytolytic than non-adherent cells against NK-sensitive and resistant tumor cells. Incubation of normal whole human blood for 1 h induces Pinocchio morphology of mononuclear white blood cells.

Original language	English
Pages (from-to)	313-320
Number of pages	8
Journal	Immunology Letters
Volume	19
Issue number	4
DOIs	https://doi.org/10.1016/0165-2478(88)90161-7
State	Published - Dec 1988

Keywords

Interleukin 2
Lymphocyte
Pinocchio cells

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10.1016/0165-2478(88)90161-7

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title = "Pinocchio cells: morphologically atypical immunologically heterogeneous lymphocytes induced by treatment with interleukin 2",

abstract = "We describe a novel cell type, the Pinocchio cell, that appears in the peripheral blood of all patients receiving treatment with interleukin 2, up to 20000 cells/μl. This cell is characterized by a prominent and granular proboscis with which it attaches to tumor cells and mediates tumor cell lysis. Pinocchio cells are immunologically heterogeneous and express antigens of both T and NK cells; Pinocchio cells are adherent in culture and are more cytolytic than non-adherent cells against NK-sensitive and resistant tumor cells. Incubation of normal whole human blood for 1 h induces Pinocchio morphology of mononuclear white blood cells.",

keywords = "Interleukin 2, Lymphocyte, Pinocchio cells",

author = "Paciucci, {Paolo Alberto} and Chesa, {Pilar Garin} and Fierro, {Maria Teresa} and Ronald Gordon and Konefal, {Robert G.} and Oliver Glidewell and Holland, {James F.}",

note = "Funding Information: Supportedin part by: Cancer CenterC ore Grant No. 5-P30-CA23102-08th, e T. J. Martell Foundation for Leukemia, Cancearn dAIDS ResearchT, he ChemotherapFyo undationa ndthe Jeffrey Forlenza Fund for Leukemiaa nd Cancer Research.",

year = "1988",

month = dec,

doi = "10.1016/0165-2478(88)90161-7",

language = "English",

volume = "19",

pages = "313--320",

journal = "Immunology Letters",

issn = "0165-2478",

publisher = "Elsevier",

number = "4",

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TY - JOUR

T1 - Pinocchio cells

T2 - morphologically atypical immunologically heterogeneous lymphocytes induced by treatment with interleukin 2

AU - Paciucci, Paolo Alberto

AU - Chesa, Pilar Garin

AU - Fierro, Maria Teresa

AU - Gordon, Ronald

AU - Konefal, Robert G.

AU - Glidewell, Oliver

AU - Holland, James F.

N1 - Funding Information: Supportedin part by: Cancer CenterC ore Grant No. 5-P30-CA23102-08th, e T. J. Martell Foundation for Leukemia, Cancearn dAIDS ResearchT, he ChemotherapFyo undationa ndthe Jeffrey Forlenza Fund for Leukemiaa nd Cancer Research.

PY - 1988/12

Y1 - 1988/12

N2 - We describe a novel cell type, the Pinocchio cell, that appears in the peripheral blood of all patients receiving treatment with interleukin 2, up to 20000 cells/μl. This cell is characterized by a prominent and granular proboscis with which it attaches to tumor cells and mediates tumor cell lysis. Pinocchio cells are immunologically heterogeneous and express antigens of both T and NK cells; Pinocchio cells are adherent in culture and are more cytolytic than non-adherent cells against NK-sensitive and resistant tumor cells. Incubation of normal whole human blood for 1 h induces Pinocchio morphology of mononuclear white blood cells.

AB - We describe a novel cell type, the Pinocchio cell, that appears in the peripheral blood of all patients receiving treatment with interleukin 2, up to 20000 cells/μl. This cell is characterized by a prominent and granular proboscis with which it attaches to tumor cells and mediates tumor cell lysis. Pinocchio cells are immunologically heterogeneous and express antigens of both T and NK cells; Pinocchio cells are adherent in culture and are more cytolytic than non-adherent cells against NK-sensitive and resistant tumor cells. Incubation of normal whole human blood for 1 h induces Pinocchio morphology of mononuclear white blood cells.

KW - Interleukin 2

KW - Lymphocyte

KW - Pinocchio cells

UR - http://www.scopus.com/inward/record.url?scp=0024274035&partnerID=8YFLogxK

U2 - 10.1016/0165-2478(88)90161-7

DO - 10.1016/0165-2478(88)90161-7

M3 - Article

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AN - SCOPUS:0024274035

VL - 19

SP - 313

EP - 320

JO - Immunology Letters

JF - Immunology Letters

SN - 0165-2478

IS - 4

ER -

Pinocchio cells: morphologically atypical immunologically heterogeneous lymphocytes induced by treatment with interleukin 2

Abstract

Keywords

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