Pinocchio cells: morphologically atypical immunologically heterogeneous lymphocytes induced by treatment with interleukin 2

Paolo Alberto Paciucci, Pilar Garin Chesa, Maria Teresa Fierro, Ronald Gordon, Robert G. Konefal, Oliver Glidewell, James F. Holland

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

We describe a novel cell type, the Pinocchio cell, that appears in the peripheral blood of all patients receiving treatment with interleukin 2, up to 20000 cells/μl. This cell is characterized by a prominent and granular proboscis with which it attaches to tumor cells and mediates tumor cell lysis. Pinocchio cells are immunologically heterogeneous and express antigens of both T and NK cells; Pinocchio cells are adherent in culture and are more cytolytic than non-adherent cells against NK-sensitive and resistant tumor cells. Incubation of normal whole human blood for 1 h induces Pinocchio morphology of mononuclear white blood cells.

Original languageEnglish
Pages (from-to)313-320
Number of pages8
JournalImmunology Letters
Volume19
Issue number4
DOIs
StatePublished - Dec 1988

Keywords

  • Interleukin 2
  • Lymphocyte
  • Pinocchio cells

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