PINning down the c-Myc oncoprotein

David Dominguez-Sola; Riccardo Dalla-Favera

doi:10.1038/ncb0404-288

PINning down the c-Myc oncoprotein

David Dominguez-Sola, Riccardo Dalla-Favera

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

The proto-oncogenic transcription factor c-Myc is a central regulator of the cell cycle and cell growth. Amino-terminal phosphorylation of c-Myc results in its proteasomal degradation. A new study shows that its dephosphorylation is regulated by the Pin1 prolyl isomerase and PP2A phosphatase, and that stabilized c-Myc can replace SV40 small T antigen in the oncogenic transformation of human cells.

Original language	English
Pages (from-to)	288-289
Number of pages	2
Journal	Nature Cell Biology
Volume	6
Issue number	4
DOIs	https://doi.org/10.1038/ncb0404-288
State	Published - Apr 2004
Externally published	Yes

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abstract = "The proto-oncogenic transcription factor c-Myc is a central regulator of the cell cycle and cell growth. Amino-terminal phosphorylation of c-Myc results in its proteasomal degradation. A new study shows that its dephosphorylation is regulated by the Pin1 prolyl isomerase and PP2A phosphatase, and that stabilized c-Myc can replace SV40 small T antigen in the oncogenic transformation of human cells.",

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AB - The proto-oncogenic transcription factor c-Myc is a central regulator of the cell cycle and cell growth. Amino-terminal phosphorylation of c-Myc results in its proteasomal degradation. A new study shows that its dephosphorylation is regulated by the Pin1 prolyl isomerase and PP2A phosphatase, and that stabilized c-Myc can replace SV40 small T antigen in the oncogenic transformation of human cells.

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PINning down the c-Myc oncoprotein

Abstract

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