Pig model of increased cardiac afterload induced by ascending aortic banding

Olympia Bikou, Satoshi Miyashita, Kiyotake Ishikawa

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

8 Scopus citations

Abstract

Increase in cardiac afterload as, represented by hypertension is an established risk factor for cardiovascular diseases. Animal models of increased cardiac afterload offer studies aiming at identifying key molecular mechanisms and developing new therapeutic approaches. We have reported that banding of the ascending aorta in pigs results in significant cardiac hypertrophy and increased myocardial fibrosis at the chronic stages. These changes were accompanied by increased stiffness of the heart, but not by systolic dysfunction. In this chapter, we describe methods to surgically band the ascending aorta in pigs. After 3, months, animals develop systolic left ventricular pressure of >200, mmHg with above described changes in the heart.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages337-342
Number of pages6
DOIs
StatePublished - 2018

Publication series

NameMethods in Molecular Biology
Volume1816
ISSN (Print)1064-3745

Keywords

  • Chronic
  • Diastolic dysfunction
  • HFpEF
  • Heart failure
  • Hypertrophic
  • Large animal

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