Piecing together the orbitofrontal puzzle.

Catherine Elorette, Atsushi Fujimoto, J. Megan Fredericks, Frederic M. Stoll, Brian E. Russ, Peter H. Rudebeck

Research output: Contribution to journalArticlepeer-review

Abstract

For almost a century, researchers have puzzled over how the orbitofrontal cortex (OFC) contributes to behavior. Our understanding of the functions of this area has evolved as each new finding and piece of information is added to complete the larger picture. Despite this, the full picture of OFC function is incomplete. Here we begin by reviewing recent (and not so recent) theories of how OFC contributes to behavior. We then go onto highlight emerging work that has helped to broaden perspectives on the role that OFC plays in contingent learning, interoception, and social behavior. How OFC contributes to these aspects of behavior is not well understood. Here we argue that only by establishing where and how these and other functions fit within the puzzle of OFC, either alone or as part of larger brain-wide circuits, will we be able to fully realize the functions of this area.

Original languageEnglish
Pages (from-to)301-311
Number of pages11
JournalBehavioral Neuroscience
Volume135
Issue number2
DOIs
StatePublished - 2021

Keywords

  • emotion
  • interoception
  • learning
  • orbitofrontal cortex
  • prefrontal cortex

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