Physostigmine: Improvement of long-term memory processes in normal humans

Kenneth L. Davis; Richard C. Mohs; Jared R. Tinklenberg; Adolf Pfefferbaum; Leo E. Hollister; Bert S. Kopell

doi:10.1126/science.351807

Physostigmine: Improvement of long-term memory processes in normal humans

Kenneth L. Davis, Richard C. Mohs, Jared R. Tinklenberg, Adolf Pfefferbaum, Leo E. Hollister, Bert S. Kopell

Research output: Contribution to journal › Article › peer-review

330 Scopus citations

Abstract

Nineteen normal male subjects received 1.0 milligram of physostigmine or 1.0 milligram of saline by a slow intravenous infusion on two nonconsecutive days. Physostigmine significantly enhanced storage of information into long-term memory. Retrieval of information from long-term memory was also improved. Short-term memory processes were not significantly altered by physostigmine.

Original language	English
Pages (from-to)	272-274
Number of pages	3
Journal	Science
Volume	201
Issue number	4352
DOIs	https://doi.org/10.1126/science.351807
State	Published - 1978
Externally published	Yes

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title = "Physostigmine: Improvement of long-term memory processes in normal humans",

abstract = "Nineteen normal male subjects received 1.0 milligram of physostigmine or 1.0 milligram of saline by a slow intravenous infusion on two nonconsecutive days. Physostigmine significantly enhanced storage of information into long-term memory. Retrieval of information from long-term memory was also improved. Short-term memory processes were not significantly altered by physostigmine.",

author = "Davis, \{Kenneth L.\} and Mohs, \{Richard C.\} and Tinklenberg, \{Jared R.\} and Adolf Pfefferbaum and Hollister, \{Leo E.\} and Kopell, \{Bert S.\}",

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AU - Davis, Kenneth L.

AU - Mohs, Richard C.

AU - Tinklenberg, Jared R.

AU - Pfefferbaum, Adolf

AU - Hollister, Leo E.

AU - Kopell, Bert S.

PY - 1978

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N2 - Nineteen normal male subjects received 1.0 milligram of physostigmine or 1.0 milligram of saline by a slow intravenous infusion on two nonconsecutive days. Physostigmine significantly enhanced storage of information into long-term memory. Retrieval of information from long-term memory was also improved. Short-term memory processes were not significantly altered by physostigmine.

AB - Nineteen normal male subjects received 1.0 milligram of physostigmine or 1.0 milligram of saline by a slow intravenous infusion on two nonconsecutive days. Physostigmine significantly enhanced storage of information into long-term memory. Retrieval of information from long-term memory was also improved. Short-term memory processes were not significantly altered by physostigmine.

UR - https://www.scopus.com/pages/publications/0018147740

U2 - 10.1126/science.351807

DO - 10.1126/science.351807

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VL - 201

SP - 272

EP - 274

JO - Science

JF - Science

IS - 4352

ER -

Physostigmine: Improvement of long-term memory processes in normal humans

Abstract

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