Physiological interpretations based on lumped element models fit to respiratory impedance data: Use of forward-inverse modeling

K. R. Lutchen, K. D. Costa

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

Respiratory impedance (Z(rs)) data at lower (< 4 Hz) and higher (>32 Hz) frequencies require more complicated inverse models than the standard series combination of a respiratory resistance, inertance, and compliance. In this paper, a forward-inverse modeling approach was used to provide insight on how the parameters in these more complicated inverse models reflect the true physiological system. Forward models are set up to incorporate explicit physiological and anatomical detail. Simulated forward data are then fit with identifiable inverse models and the parameter estimates related to the known detail in the forward model. It is shown that inverse fitting of low frequency data alone will not allow a distinction between frequency dependence due to airway inhomogeneities and frequency dependence due to tissue viscoelasticity. With higher frequency data, a forward model based on an asymmetric branching airways network was used to simulate Z(rs) from 0.1-128 Hz with increasing amounts of nonuniform peripheral airway obstruction. Here, inverse modeling is more amenable to sensibly separating estimates of airway and tissue properties. A key result, however, is that changes in the tissue parameters of an inverse model (which provides an excellent fit to Z(rs) data) will appropriately occur in response to inhomogeneous alterations in airway diameters only. The apparent altered tissue properties reflect the decreased communication of some tissue segments with the airway opening and not an explicit change at the tissue level. These phenomena present a substantial problem for the inverse modeler. Finally, inverse model fitting of low and high frequency Z(rs) data simultaneously with a single model is not helpful for extracting additional physiological detail. Instead, separate models should be applied to each frequency range.

Original languageEnglish
Pages (from-to)1076-1086
Number of pages11
JournalIEEE Transactions on Biomedical Engineering
Volume37
Issue number11
DOIs
StatePublished - Nov 1990
Externally publishedYes

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