Physiological influences on perfusion imaging in transient myocardial ischaemia: Importance of early distribution of thallium-201

Randolph E. Patterson; Doris A. Halgash; Steven F. Horowitz; Kenneth Miceli; Calvin Eng; Stanley J. Goldsmith

doi:10.1093/cvr/16.1.47

Physiological influences on perfusion imaging in transient myocardial ischaemia: Importance of early distribution of thallium-201

Randolph E. Patterson, Doris A. Halgash, Steven F. Horowitz, Kenneth Miceli, Calvin Eng, Stanley J. Goldsmith

Research output: Contribution to journal › Review article › peer-review

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Abstract

Summary: We tested the hypothesis that visualisation of defects on thallium-201 (²⁰¹T1) myocardial perfusion images (MPI) depends on the duration of the ischaemic state between ²⁰¹T1 injection and the time of reperfusion of an occluded coronary artery. Praecordial imaging with a gamma camera was performed in 24 anaesthetised, open-chest dogs with transient coronary occlusion. Results indicated that if the duration of the ischaemic state after ²⁰¹T1 injection was less than 3 min before reperfusion, then the MPI 5 to 15 min after ²⁰¹T1 injection was falsely negative (²⁰¹T1 activity in ischaemic zone (IZ)/normal zone (NZ)>0.85). Dogs which were ischaemic more than 5 min always had MPI defects 5 to 15 min after ²⁰¹T1 injection (IZ/NZ ²⁰¹T1 ratio<0.85). MPI results (²⁰¹T1 IZ/NZ)15 min after ²⁰¹T1 injection were determined by the duration of the ischaemic state after ²⁰¹T1 injection (r= -0.86) because prolonged ischaemia allowed ²⁰¹T1 to distribute from blood to myocardium before reperfusion: ²⁰¹T1 (IZ/NZ)=0.356± 1.00 (fraction of total ²⁰¹T1 remaining in blood at the end of the ischaemic state), r=0.94.

Original language	English
Pages (from-to)	47-54
Number of pages	8
Journal	Cardiovascular Research
Volume	16
Issue number	1
DOIs	https://doi.org/10.1093/cvr/16.1.47
State	Published - Jan 1982
Externally published	Yes

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@article{b7216a979b0f4bee9e3fd86f3b0f04cd,

title = "Physiological influences on perfusion imaging in transient myocardial ischaemia: Importance of early distribution of thallium-201",

abstract = "Summary: We tested the hypothesis that visualisation of defects on thallium-201 (201T1) myocardial perfusion images (MPI) depends on the duration of the ischaemic state between 201T1 injection and the time of reperfusion of an occluded coronary artery. Praecordial imaging with a gamma camera was performed in 24 anaesthetised, open-chest dogs with transient coronary occlusion. Results indicated that if the duration of the ischaemic state after 201T1 injection was less than 3 min before reperfusion, then the MPI 5 to 15 min after 201T1 injection was falsely negative (201T1 activity in ischaemic zone (IZ)/normal zone (NZ)>0.85). Dogs which were ischaemic more than 5 min always had MPI defects 5 to 15 min after 201T1 injection (IZ/NZ 201T1 ratio<0.85). MPI results (201T1 IZ/NZ)15 min after 201T1 injection were determined by the duration of the ischaemic state after 201T1 injection (r= -0.86) because prolonged ischaemia allowed 201T1 to distribute from blood to myocardium before reperfusion: 201T1 (IZ/NZ)=0.356± 1.00 (fraction of total 201T1 remaining in blood at the end of the ischaemic state), r=0.94.",

author = "Patterson, {Randolph E.} and Halgash, {Doris A.} and Horowitz, {Steven F.} and Kenneth Miceli and Calvin Eng and Goldsmith, {Stanley J.}",

note = "Funding Information: Supported in part by N.H.L.B.I. Grants No. HL 20163, a grant-in-aid from the New York Heart Association, The Heart Research Foundation, The Kriendler Bems Foundation, and a Young Investigator Research Award from N.H.L.B.I. to Dr. Patterson, No. 1R23 HL 2115.",

year = "1982",

month = jan,

doi = "10.1093/cvr/16.1.47",

language = "English",

volume = "16",

pages = "47--54",

journal = "Cardiovascular Research",

issn = "0008-6363",

publisher = "Oxford University Press",

number = "1",

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T1 - Physiological influences on perfusion imaging in transient myocardial ischaemia

T2 - Importance of early distribution of thallium-201

AU - Patterson, Randolph E.

AU - Halgash, Doris A.

AU - Horowitz, Steven F.

AU - Miceli, Kenneth

AU - Eng, Calvin

AU - Goldsmith, Stanley J.

N1 - Funding Information: Supported in part by N.H.L.B.I. Grants No. HL 20163, a grant-in-aid from the New York Heart Association, The Heart Research Foundation, The Kriendler Bems Foundation, and a Young Investigator Research Award from N.H.L.B.I. to Dr. Patterson, No. 1R23 HL 2115.

PY - 1982/1

Y1 - 1982/1

N2 - Summary: We tested the hypothesis that visualisation of defects on thallium-201 (201T1) myocardial perfusion images (MPI) depends on the duration of the ischaemic state between 201T1 injection and the time of reperfusion of an occluded coronary artery. Praecordial imaging with a gamma camera was performed in 24 anaesthetised, open-chest dogs with transient coronary occlusion. Results indicated that if the duration of the ischaemic state after 201T1 injection was less than 3 min before reperfusion, then the MPI 5 to 15 min after 201T1 injection was falsely negative (201T1 activity in ischaemic zone (IZ)/normal zone (NZ)>0.85). Dogs which were ischaemic more than 5 min always had MPI defects 5 to 15 min after 201T1 injection (IZ/NZ 201T1 ratio<0.85). MPI results (201T1 IZ/NZ)15 min after 201T1 injection were determined by the duration of the ischaemic state after 201T1 injection (r= -0.86) because prolonged ischaemia allowed 201T1 to distribute from blood to myocardium before reperfusion: 201T1 (IZ/NZ)=0.356± 1.00 (fraction of total 201T1 remaining in blood at the end of the ischaemic state), r=0.94.

AB - Summary: We tested the hypothesis that visualisation of defects on thallium-201 (201T1) myocardial perfusion images (MPI) depends on the duration of the ischaemic state between 201T1 injection and the time of reperfusion of an occluded coronary artery. Praecordial imaging with a gamma camera was performed in 24 anaesthetised, open-chest dogs with transient coronary occlusion. Results indicated that if the duration of the ischaemic state after 201T1 injection was less than 3 min before reperfusion, then the MPI 5 to 15 min after 201T1 injection was falsely negative (201T1 activity in ischaemic zone (IZ)/normal zone (NZ)>0.85). Dogs which were ischaemic more than 5 min always had MPI defects 5 to 15 min after 201T1 injection (IZ/NZ 201T1 ratio<0.85). MPI results (201T1 IZ/NZ)15 min after 201T1 injection were determined by the duration of the ischaemic state after 201T1 injection (r= -0.86) because prolonged ischaemia allowed 201T1 to distribute from blood to myocardium before reperfusion: 201T1 (IZ/NZ)=0.356± 1.00 (fraction of total 201T1 remaining in blood at the end of the ischaemic state), r=0.94.

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U2 - 10.1093/cvr/16.1.47

DO - 10.1093/cvr/16.1.47

M3 - Review article

C2 - 7060060

AN - SCOPUS:85047675959

SN - 0008-6363

VL - 16

SP - 47

EP - 54

JO - Cardiovascular Research

JF - Cardiovascular Research

IS - 1

ER -

Physiological influences on perfusion imaging in transient myocardial ischaemia: Importance of early distribution of thallium-201

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