TY - JOUR
T1 - Physiological functions of programmed DNA breaks in signal-induced transcription
AU - Puc, Janusz
AU - Aggarwal, Aneel K.
AU - Rosenfeld, Michael G.
N1 - Funding Information:
This work was supported by DK 018477, DK 039949, and CA17390. M.G.R. is an Investigator with the Howard Hughes Medical Institute (HHMI).
Publisher Copyright:
© 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
PY - 2017/8/1
Y1 - 2017/8/1
N2 - The idea that signal-dependent transcription might involve the generation of transient DNA nicks or even breaks in the regulatory regions of genes, accompanied by activation of DNA damage repair pathways, would seem to be counterintuitive, as DNA damage is usually considered harmful to cellular integrity. However, recent studies have generated a substantial body of evidence that now argues that programmed DNA single- or double-strand breaks can, at least in specific cases, have a role in transcription regulation. Here, we discuss the emerging functions of DNA breaks in the relief of DNA torsional stress and in promoter and enhancer activation.
AB - The idea that signal-dependent transcription might involve the generation of transient DNA nicks or even breaks in the regulatory regions of genes, accompanied by activation of DNA damage repair pathways, would seem to be counterintuitive, as DNA damage is usually considered harmful to cellular integrity. However, recent studies have generated a substantial body of evidence that now argues that programmed DNA single- or double-strand breaks can, at least in specific cases, have a role in transcription regulation. Here, we discuss the emerging functions of DNA breaks in the relief of DNA torsional stress and in promoter and enhancer activation.
UR - http://www.scopus.com/inward/record.url?scp=85026900421&partnerID=8YFLogxK
U2 - 10.1038/nrm.2017.43
DO - 10.1038/nrm.2017.43
M3 - Review article
C2 - 28537575
AN - SCOPUS:85026900421
SN - 1471-0072
VL - 18
SP - 471
EP - 476
JO - Nature Reviews Molecular Cell Biology
JF - Nature Reviews Molecular Cell Biology
IS - 8
ER -