Physiological consequences of loss of plasminogen activator gene function in mice

Peter Carmeliet; Luc Schoonjans; Lena Kieckens; Beverly Ream; Jay Degen; Roderick Bronson; Rita De Vos; Joost J. Van Den Oord; Désiré Collen; Richard C. Mulligan

doi:10.1038/368419a0

Physiological consequences of loss of plasminogen activator gene function in mice

Peter Carmeliet, Luc Schoonjans, Lena Kieckens, Beverly Ream, Jay Degen, Roderick Bronson, Rita De Vos, Joost J. Van Den Oord, Désiré Collen, Richard C. Mulligan

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Abstract

Indirect evidence suggests a crucial role for the fibrinolytic system and its physiological triggers, tissue-type (t-PA) and urokinase-type (u-PA) plasminogen activator, in many proteolytic processes. Inactivation of the t-PA gene impairs clot lysis and inactivation of the u-PA gene results in occasional fibrin deposition. Mice with combined t-PA and u-PA deficiency suffer extensive spontaneous fibrin deposition, with its associated effects on growth, fertility and survival.

Original language	English
Pages (from-to)	419-424
Number of pages	6
Journal	Nature
Volume	368
Issue number	6470
DOIs	https://doi.org/10.1038/368419a0
State	Published - 1994
Externally published	Yes

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abstract = "Indirect evidence suggests a crucial role for the fibrinolytic system and its physiological triggers, tissue-type (t-PA) and urokinase-type (u-PA) plasminogen activator, in many proteolytic processes. Inactivation of the t-PA gene impairs clot lysis and inactivation of the u-PA gene results in occasional fibrin deposition. Mice with combined t-PA and u-PA deficiency suffer extensive spontaneous fibrin deposition, with its associated effects on growth, fertility and survival.",

author = "Peter Carmeliet and Luc Schoonjans and Lena Kieckens and Beverly Ream and Jay Degen and Roderick Bronson and {De Vos}, Rita and {Van Den Oord}, {Joost J.} and D{\'e}sir{\'e} Collen and Mulligan, {Richard C.}",

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AU - Carmeliet, Peter

AU - Schoonjans, Luc

AU - Kieckens, Lena

AU - Ream, Beverly

AU - Degen, Jay

AU - Bronson, Roderick

AU - De Vos, Rita

AU - Van Den Oord, Joost J.

AU - Collen, Désiré

AU - Mulligan, Richard C.

PY - 1994

Y1 - 1994

N2 - Indirect evidence suggests a crucial role for the fibrinolytic system and its physiological triggers, tissue-type (t-PA) and urokinase-type (u-PA) plasminogen activator, in many proteolytic processes. Inactivation of the t-PA gene impairs clot lysis and inactivation of the u-PA gene results in occasional fibrin deposition. Mice with combined t-PA and u-PA deficiency suffer extensive spontaneous fibrin deposition, with its associated effects on growth, fertility and survival.

AB - Indirect evidence suggests a crucial role for the fibrinolytic system and its physiological triggers, tissue-type (t-PA) and urokinase-type (u-PA) plasminogen activator, in many proteolytic processes. Inactivation of the t-PA gene impairs clot lysis and inactivation of the u-PA gene results in occasional fibrin deposition. Mice with combined t-PA and u-PA deficiency suffer extensive spontaneous fibrin deposition, with its associated effects on growth, fertility and survival.

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EP - 424

JO - Nature

JF - Nature

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ER -

Physiological consequences of loss of plasminogen activator gene function in mice

Abstract

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