Physiological Actions of Parathyroid Hormone (PTH) and PTH-Related Protein: Epidermal, Mammary, Reproductive, Pancreatic Tissues

John J. Wysolmerski, Andrew F. Stewart, Christopher S. Kovacs

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

5 Scopus citations

Abstract

Advances in mouse genetics and in transgenic technology have been a boon to the study of physiology. This has certainly been the case for the PTHrP field, where studies in genetically altered mice have provided a starting place for the study of the physiology of a protein that was discovered outside its natural context. This chapter outlines the current state of knowledge regarding the physiological roles of PTHrP in skin, the mammary gland, placenta, uterus, and pancreas. It considers the functions of PTHrP in skin. Following this, it reviews its functions in the mammary gland, placenta, and other reproductive tissues. Finally, it examines its role in the endocrine pancreas. It concludes bys stating that much of this information has come from studies performed in a variety of transgenic mice. These studies have shown that PTHrP is important to both the development and the physiological functioning of these organs. However, at this point, there continue to be as many questions as answers. There are many experiments to be done before all the nuances of the functions of PTHrP at these sites can be comprehended. The next several years promise to see continued progress in the investigation of the nonskeletal effects of this remarkable molecule.

Original languageEnglish
Title of host publicationPrinciples of Bone Biology
Subtitle of host publicationVolume 1-2, Third Edition
PublisherElsevier
Pages713-731
Number of pages19
ISBN (Electronic)9780123738844
DOIs
StatePublished - 1 Jan 2008
Externally publishedYes

Fingerprint

Dive into the research topics of 'Physiological Actions of Parathyroid Hormone (PTH) and PTH-Related Protein: Epidermal, Mammary, Reproductive, Pancreatic Tissues'. Together they form a unique fingerprint.

Cite this