TY - CHAP
T1 - Physiological Actions of Parathyroid Hormone (PTH) and PTH-Related Protein
T2 - Epidermal, Mammary, Reproductive, Pancreatic Tissues
AU - Wysolmerski, John J.
AU - Stewart, Andrew F.
AU - Kovacs, Christopher S.
N1 - Publisher Copyright:
© 2008 Elsevier Inc. All rights reserved.
PY - 2008/1/1
Y1 - 2008/1/1
N2 - Advances in mouse genetics and in transgenic technology have been a boon to the study of physiology. This has certainly been the case for the PTHrP field, where studies in genetically altered mice have provided a starting place for the study of the physiology of a protein that was discovered outside its natural context. This chapter outlines the current state of knowledge regarding the physiological roles of PTHrP in skin, the mammary gland, placenta, uterus, and pancreas. It considers the functions of PTHrP in skin. Following this, it reviews its functions in the mammary gland, placenta, and other reproductive tissues. Finally, it examines its role in the endocrine pancreas. It concludes bys stating that much of this information has come from studies performed in a variety of transgenic mice. These studies have shown that PTHrP is important to both the development and the physiological functioning of these organs. However, at this point, there continue to be as many questions as answers. There are many experiments to be done before all the nuances of the functions of PTHrP at these sites can be comprehended. The next several years promise to see continued progress in the investigation of the nonskeletal effects of this remarkable molecule.
AB - Advances in mouse genetics and in transgenic technology have been a boon to the study of physiology. This has certainly been the case for the PTHrP field, where studies in genetically altered mice have provided a starting place for the study of the physiology of a protein that was discovered outside its natural context. This chapter outlines the current state of knowledge regarding the physiological roles of PTHrP in skin, the mammary gland, placenta, uterus, and pancreas. It considers the functions of PTHrP in skin. Following this, it reviews its functions in the mammary gland, placenta, and other reproductive tissues. Finally, it examines its role in the endocrine pancreas. It concludes bys stating that much of this information has come from studies performed in a variety of transgenic mice. These studies have shown that PTHrP is important to both the development and the physiological functioning of these organs. However, at this point, there continue to be as many questions as answers. There are many experiments to be done before all the nuances of the functions of PTHrP at these sites can be comprehended. The next several years promise to see continued progress in the investigation of the nonskeletal effects of this remarkable molecule.
UR - http://www.scopus.com/inward/record.url?scp=78149428949&partnerID=8YFLogxK
U2 - 10.1016/B978-0-12-373884-4.00051-3
DO - 10.1016/B978-0-12-373884-4.00051-3
M3 - Chapter
AN - SCOPUS:78149428949
SP - 713
EP - 731
BT - Principles of Bone Biology
PB - Elsevier
ER -