Physicians' Health Study: Aspirin and Primary Prevention of Coronary Heart Disease

The Steering Committee of the Physicians' Health Study Research Group

Research output: Contribution to journalLetterpeer-review

53 Scopus citations


To the Editor: Both the U.S. Physicians' Health Study (July 20 issue)1 and the British Doctors' Study2 found no significant differences in mortality from all causes or from cardiovascular disease between aspirin-treated and placebo or untreated groups. The British study also found no differences in event rates for nonfatal or fatal myocardial infarction. In contrast, the U.S. study reported a significant reduction in rates of nonfatal and fatal myocardial infarction in the aspirin-treated group, leading to the authors' conclusion that aspirin treatment is protective overall against coronary heart disease. In the U.S. study, although the death rates for acute myocardial….

Original languageEnglish
Pages (from-to)1825-1828
Number of pages4
JournalNew England Journal of Medicine
Issue number26
StatePublished - 28 Dec 1989


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