TY - JOUR
T1 - Physical activity and survival of postmenopausal, hormone receptor-positive breast cancer patients
T2 - Results of the Tamoxifen Exemestane Adjuvant Multicenter Lifestyle study
AU - De Glas, Nienke A.
AU - Fontein, Duveken B.Y.
AU - Bastiaannet, Esther
AU - Pijpe, Anouk
AU - De Craen, Anton J.M.
AU - Liefers, Gerrit Jan
AU - Nortier, Hans J.R.
AU - De Haes, Hanneke J.C.J.M.
AU - Van De Velde, Cornelis J.H.
AU - Van Leeuwen, Flora E.
N1 - Publisher Copyright:
© 2014 American Cancer Society.
PY - 2014/9/1
Y1 - 2014/9/1
N2 - BACKGROUND: Physical activity has been related to improved breast cancer outcomes. Especially in the older breast cancer population, physical activity may be important because old age is associated with comorbidities and decreased physical function. The purpose of this study was to investigate the relation between physical activity and overall survival, breast cancer-specific survival, and recurrence in several age groups of postmenopausal breast cancer patients. METHODS: The Tamoxifen Exemestane Adjuvant Multinational Lifestyle study was a side study of the Tamoxifen Exemestane Adjuvant Multinational trial and prospectively investigated lifestyle habits of postmenopausal, hormone receptor-positive breast cancer patients. The relations between prediagnosis and postdiagnosis physical activity and overall survival, breast cancer-specific survival, and recurrence-free survival were assessed with Cox regression and competing risk regression models. RESULTS: Among 521 patients, high levels of physical activity before and after the diagnosis were associated with better overall survival (the multivariate hazard ratios were 0.50 [95% confidence interval50.26-0.98] and 0.57 (95% confidence interval50.26-1.40] for patients who were very active before and after the diagnosis, respectively, in comparison with inactive patients). This was most evident in patients who were 65 years old or older. Physical activity was not significantly associated with breast cancer-specific survival or the relapse-free period. CONCLUSIONS: Overall survival was better for patients who were active before and after the diagnosis. In contrast with previous studies, breast cancer survival and the risk of recurrence were not significantly associated with physical activity. These findings confirmed the need for more studies investigating the use of physical activity to supplement breast cancer treatment in older patients.
AB - BACKGROUND: Physical activity has been related to improved breast cancer outcomes. Especially in the older breast cancer population, physical activity may be important because old age is associated with comorbidities and decreased physical function. The purpose of this study was to investigate the relation between physical activity and overall survival, breast cancer-specific survival, and recurrence in several age groups of postmenopausal breast cancer patients. METHODS: The Tamoxifen Exemestane Adjuvant Multinational Lifestyle study was a side study of the Tamoxifen Exemestane Adjuvant Multinational trial and prospectively investigated lifestyle habits of postmenopausal, hormone receptor-positive breast cancer patients. The relations between prediagnosis and postdiagnosis physical activity and overall survival, breast cancer-specific survival, and recurrence-free survival were assessed with Cox regression and competing risk regression models. RESULTS: Among 521 patients, high levels of physical activity before and after the diagnosis were associated with better overall survival (the multivariate hazard ratios were 0.50 [95% confidence interval50.26-0.98] and 0.57 (95% confidence interval50.26-1.40] for patients who were very active before and after the diagnosis, respectively, in comparison with inactive patients). This was most evident in patients who were 65 years old or older. Physical activity was not significantly associated with breast cancer-specific survival or the relapse-free period. CONCLUSIONS: Overall survival was better for patients who were active before and after the diagnosis. In contrast with previous studies, breast cancer survival and the risk of recurrence were not significantly associated with physical activity. These findings confirmed the need for more studies investigating the use of physical activity to supplement breast cancer treatment in older patients.
KW - Breast cancer
KW - Endocrine therapy
KW - Older patients
KW - Physical activity
KW - Postmenopausal patients
UR - http://www.scopus.com/inward/record.url?scp=84908025484&partnerID=8YFLogxK
U2 - 10.1002/cncr.28783
DO - 10.1002/cncr.28783
M3 - Article
C2 - 24840230
AN - SCOPUS:84908025484
SN - 0008-543X
VL - 120
SP - 2847
EP - 2854
JO - Cancer
JF - Cancer
IS - 18
ER -