TY - JOUR
T1 - Physical activity and lymphoid neoplasms in the European Prospective Investigation into Cancer and nutrition (EPIC)
AU - Van Veldhoven, Catharina M.
AU - Khan, Aneire E.
AU - Teucher, Birgit
AU - Rohrmann, Sabine
AU - Raaschou-Nielsen, Ole
AU - Tjønneland, Anne
AU - Overvad, Kim
AU - Vigl, Matthaeus
AU - Boeing, Heiner
AU - Benetou, Vassiliki
AU - Trichopoulou, Antonia
AU - Trichopoulos, Dimitrios
AU - Masala, Giovanna
AU - Mattiello, Amalia
AU - Krogh, Vittorio
AU - Tumino, Rosario
AU - Vermeulen, Roel
AU - Monninkhof, Evelyn
AU - May, Anne M.
AU - Bueno-De-Mesquita, Bas
AU - Lund, Eiliv
AU - Ardanaz, Eva
AU - Huerta, José María
AU - Jakszyn, Paula
AU - Dorronsoro, Miren
AU - Argüelles, Marcial
AU - Sánchez, Maria José
AU - Hallmans, Göran
AU - Manjer, Jonas
AU - Borgquist, Signe
AU - Allen, Naomi E.
AU - Travis, Ruth C.
AU - Khaw, Kay Tee
AU - Wareham, Nick
AU - Boffetta, Paolo
AU - Vineis, Paolo
AU - Riboli, Elio
N1 - Funding Information:
This work was supported by Europe against Cancer Program of the European Commission (SANCO) ; Deutsche Krebshilfe, Deutsches Krebsforschungszentrum, German Federal Ministry of Education and Research ; Danish Cancer Society ; Health Research Fund (FIS) of the Spanish Ministry of Health, Spanish Regional Governments of Andalucia, Asturias, Basque Country, Murcia and Navarra ; the ISCIII Network RCESP (C03/09), Spain ; Cancer Research UK ; Medical Research Council, United Kingdom ; Hellenic Ministry of Health ; Stavros Niarchos Foundation ; Hellenic Health Foundation ; Italian Association for Research on Cancer (AIRC) ; Italian National Research Council, Fondazione-Istituto Banco Napoli, Italy ; Compagnia di San Paolo ; Dutch Ministry of Public Health, Welfare and Sports ; World Cancer Research Fund ; Swedish Cancer Society ; Swedish Scientific Council ; Regional Government of Skåne, Sweden ; Norwegian Cancer Society ; Research Council of Norway ; French League against Cancer (LNCC) ; National Institute for Health and Medical Research (INSERM), France ; Mutuelle Générale de l’Education Nationale (MGEN), France ; 3M Co, France ; Gustave Roussy Institute (IGR), France ; and General Councils of France .
PY - 2011/3
Y1 - 2011/3
N2 - Background: Lymphoid neoplasms are a heterogeneous group of cancers that originate in the lymphatic cells of the immune system. Several risk factors have been identified or suggested, but they all account for only a small proportion of the lymphoid neoplasm incidence. It has been hypothesised that regular exercise may modulate the immune system and thereby reduce the risk of developing the disease. Design and methods: The European Investigation into Cancer and Nutrition (EPIC) cohort consists of 521,457 adults, recruited by 23 centres in 10 European countries. The analytical cohort included 343,756 participants, with 778 non-Hodgkin lymphoma (NHL) cases (376 men and 402 women) and 690 B-cell non-Hodgkin lymphoma (B-NHL) cases (326 men and 364 women). Multivariate Cox regression models were used to calculate hazard ratios (HR) for the association between total, recreational, occupational, and household physical activity and NHL and B-NHL risk, as well as the risk for several B-NHL subtypes. Models were stratified by study centre and age at recruitment and adjusted for various potential confounding factors. Results: We found no evidence of any effect of total physical activity on NHL (adjusted p-trend = 0.76 and 0.30 for men and women, respectively) and B-NHL risk (adjusted p-trend = 0.99 and 0.21 for men and women, respectively) for either men or women. Also no robust results were found for B-NHL subtype analyses among men or women. Conclusions: This study provided no consistent evidence for an association between various physical activity measures and the risk of lymphoid neoplasms or any of the B-NHL subtypes.
AB - Background: Lymphoid neoplasms are a heterogeneous group of cancers that originate in the lymphatic cells of the immune system. Several risk factors have been identified or suggested, but they all account for only a small proportion of the lymphoid neoplasm incidence. It has been hypothesised that regular exercise may modulate the immune system and thereby reduce the risk of developing the disease. Design and methods: The European Investigation into Cancer and Nutrition (EPIC) cohort consists of 521,457 adults, recruited by 23 centres in 10 European countries. The analytical cohort included 343,756 participants, with 778 non-Hodgkin lymphoma (NHL) cases (376 men and 402 women) and 690 B-cell non-Hodgkin lymphoma (B-NHL) cases (326 men and 364 women). Multivariate Cox regression models were used to calculate hazard ratios (HR) for the association between total, recreational, occupational, and household physical activity and NHL and B-NHL risk, as well as the risk for several B-NHL subtypes. Models were stratified by study centre and age at recruitment and adjusted for various potential confounding factors. Results: We found no evidence of any effect of total physical activity on NHL (adjusted p-trend = 0.76 and 0.30 for men and women, respectively) and B-NHL risk (adjusted p-trend = 0.99 and 0.21 for men and women, respectively) for either men or women. Also no robust results were found for B-NHL subtype analyses among men or women. Conclusions: This study provided no consistent evidence for an association between various physical activity measures and the risk of lymphoid neoplasms or any of the B-NHL subtypes.
KW - Cohort study
KW - Hodgkin lymphoma
KW - Lymphocytic leukaemia
KW - Lymphoid neoplasm
KW - Multiple myeloma
KW - Non-Hodgkin lymphoma
KW - Physical activity
UR - http://www.scopus.com/inward/record.url?scp=79952101640&partnerID=8YFLogxK
U2 - 10.1016/j.ejca.2010.11.010
DO - 10.1016/j.ejca.2010.11.010
M3 - Article
C2 - 21159506
AN - SCOPUS:79952101640
SN - 0959-8049
VL - 47
SP - 748
EP - 760
JO - European Journal of Cancer
JF - European Journal of Cancer
IS - 5
ER -