Photoreceptor outer nuclear layer thickness changes in optic neuritis follow up

Masoud Aghsaei Fard, Alireza Golizadeh, Samira Yadegari, Hossein Ghahvehchian, Prem Subramanian, Robert Ritch

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Background: Ganglion cell inner plexiform (GCIP) layer thinning following acute optic neuritis (ON) is well-known. However, the onset of changes in the outer retinal layers needs further study. In this study, we determine longitudinal changes in retinal layer thickness in ON. Methods: Thirty ON patients underwent optical coherence tomography (OCT) and visual function testing at baseline, one month, and 6 months. Results: Mean GCIPL thickness decreased at one month relative to baseline from 63.6 ± 7.5 μm to 57.3 ± 6.8 µm in 3 mm ring (P < 0.001). There were no significant changes in GCIPL thickness between one and 6 months (P = 0.42). Outer nuclear layer (ONL) thickness in the 6 mm macular area increased from 58.9 ± 5.8 µm to 63.2 ± 6.8 μm at one month (P < 0.001) and then decreased at six month (58.8 ± 5.8 µm) relative to one month, reaching the baseline thickness. While GCIPL thinning at 1 month correlated with baseline visual acuity, change in the central ONL thickness from baseline to month 1 predicted visual outcome at month 6 (r = 0.6, P = 0.001). Conclusions: Following ON, transient changes occur in the photoreceptor nuclei layer and then revert to baseline. This finding could predict 6 month visual acuity after ON.

Original languageEnglish
Article number101905
JournalMultiple Sclerosis and Related Disorders
StatePublished - Apr 2020
Externally publishedYes


  • Ganglion cell
  • Optic neuritis
  • Optical coherence tomography
  • Photoreceptor nuclei


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