Photolysis of Caged Glutamate for Use in the CNS

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations

Abstract

Caged glutamate is a biologically inert, photolabile precursor of. L-glutamate, the major excitatory neurotransmitter in the central nervous system (CNS) that is used to produce concentration jumps of glutamate on neurons. Organic chemists have synthesized many chromophores for uncaging, but not all caged glutamates are made equal. A survey of these caged compounds, especially with reference to two-photon photolysis in brain slices, reveals that the ideal properties for a photolabile glutamate find their best combination in acylnitroindolinyl-caged glutamates, such as MNI-glu.

Original languageEnglish
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd.
Pages639-644
Number of pages6
ISBN (Print)9780080450469
DOIs
StatePublished - 2009
Externally publishedYes

Keywords

  • Aqueous stability
  • Caged glutamate
  • EPSC
  • Extinction coefficient
  • Organic synthesis
  • Photolysis
  • Quantum yield
  • Rate of uncaging
  • Two-photon

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