Photolysis of Caged Glutamate for Use in the CNS

G. C.R. Ellis-Davies

doi:10.1016/B978-008045046-9.00876-7

Photolysis of Caged Glutamate for Use in the CNS

G. C.R. Ellis-Davies

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Scopus citations

Abstract

Caged glutamate is a biologically inert, photolabile precursor of. L-glutamate, the major excitatory neurotransmitter in the central nervous system (CNS) that is used to produce concentration jumps of glutamate on neurons. Organic chemists have synthesized many chromophores for uncaging, but not all caged glutamates are made equal. A survey of these caged compounds, especially with reference to two-photon photolysis in brain slices, reveals that the ideal properties for a photolabile glutamate find their best combination in acylnitroindolinyl-caged glutamates, such as MNI-glu.

Original language	English
Title of host publication	Encyclopedia of Neuroscience
Publisher	Elsevier Ltd.
Pages	639-644
Number of pages	6
ISBN (Print)	9780080450469
DOIs	https://doi.org/10.1016/B978-008045046-9.00876-7
State	Published - 2009
Externally published	Yes

Keywords

Aqueous stability
Caged glutamate
EPSC
Extinction coefficient
Organic synthesis
Photolysis
Quantum yield
Rate of uncaging
Two-photon

Access to Document

10.1016/B978-008045046-9.00876-7

Cite this

@inbook{9aea08808b174df5bdf52f00b4dfe6f7,

title = "Photolysis of Caged Glutamate for Use in the CNS",

abstract = "Caged glutamate is a biologically inert, photolabile precursor of. L-glutamate, the major excitatory neurotransmitter in the central nervous system (CNS) that is used to produce concentration jumps of glutamate on neurons. Organic chemists have synthesized many chromophores for uncaging, but not all caged glutamates are made equal. A survey of these caged compounds, especially with reference to two-photon photolysis in brain slices, reveals that the ideal properties for a photolabile glutamate find their best combination in acylnitroindolinyl-caged glutamates, such as MNI-glu.",

keywords = "Aqueous stability, Caged glutamate, EPSC, Extinction coefficient, Organic synthesis, Photolysis, Quantum yield, Rate of uncaging, Two-photon",

author = "Ellis-Davies, {G. C.R.}",

year = "2009",

doi = "10.1016/B978-008045046-9.00876-7",

language = "English",

isbn = "9780080450469",

pages = "639--644",

booktitle = "Encyclopedia of Neuroscience",

publisher = "Elsevier Ltd.",

address = "United Kingdom",

}

TY - CHAP

T1 - Photolysis of Caged Glutamate for Use in the CNS

AU - Ellis-Davies, G. C.R.

PY - 2009

Y1 - 2009

N2 - Caged glutamate is a biologically inert, photolabile precursor of. L-glutamate, the major excitatory neurotransmitter in the central nervous system (CNS) that is used to produce concentration jumps of glutamate on neurons. Organic chemists have synthesized many chromophores for uncaging, but not all caged glutamates are made equal. A survey of these caged compounds, especially with reference to two-photon photolysis in brain slices, reveals that the ideal properties for a photolabile glutamate find their best combination in acylnitroindolinyl-caged glutamates, such as MNI-glu.

AB - Caged glutamate is a biologically inert, photolabile precursor of. L-glutamate, the major excitatory neurotransmitter in the central nervous system (CNS) that is used to produce concentration jumps of glutamate on neurons. Organic chemists have synthesized many chromophores for uncaging, but not all caged glutamates are made equal. A survey of these caged compounds, especially with reference to two-photon photolysis in brain slices, reveals that the ideal properties for a photolabile glutamate find their best combination in acylnitroindolinyl-caged glutamates, such as MNI-glu.

KW - Aqueous stability

KW - Caged glutamate

KW - EPSC

KW - Extinction coefficient

KW - Organic synthesis

KW - Photolysis

KW - Quantum yield

KW - Rate of uncaging

KW - Two-photon

UR - http://www.scopus.com/inward/record.url?scp=84882828795&partnerID=8YFLogxK

U2 - 10.1016/B978-008045046-9.00876-7

DO - 10.1016/B978-008045046-9.00876-7

M3 - Chapter

AN - SCOPUS:84882828795

SN - 9780080450469

SP - 639

EP - 644

BT - Encyclopedia of Neuroscience

PB - Elsevier Ltd.

ER -

Photolysis of Caged Glutamate for Use in the CNS

Abstract

Keywords

Access to Document

Fingerprint

Cite this