Photochemically-triggered decarboxylation/deamination of o-nitrodimethoxyphenylglycine

Christopher D. Woodrell; Polina D. Kehayova; Ahamindra Jain

doi:10.1021/ol9907062

Photochemically-triggered decarboxylation/deamination of o-nitrodimethoxyphenylglycine

Christopher D. Woodrell, Polina D. Kehayova, Ahamindra Jain

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

(Matrix presented) o-Nitrodimethoxyphenylglycine (1) decomposes on photolysis at 366 nm to release ammonia and carbon dioxide, via a five-step mechanism (Scheme 1). We have obtained spectroscopic and kinetic data from experiment and calculation which support our mechanism. We have also confirmed that a carbonic anhydrase inhibitor bearing 1 as a photolabile cage releases a tight-binding inhibitor on photolysis at 366 nm.

Original language	English
Pages (from-to)	619-621
Number of pages	3
Journal	Organic Letters
Volume	1
Issue number	4
DOIs	https://doi.org/10.1021/ol9907062
State	Published - 26 Aug 1999
Externally published	Yes

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title = "Photochemically-triggered decarboxylation/deamination of o-nitrodimethoxyphenylglycine",

abstract = "(Matrix presented) o-Nitrodimethoxyphenylglycine (1) decomposes on photolysis at 366 nm to release ammonia and carbon dioxide, via a five-step mechanism (Scheme 1). We have obtained spectroscopic and kinetic data from experiment and calculation which support our mechanism. We have also confirmed that a carbonic anhydrase inhibitor bearing 1 as a photolabile cage releases a tight-binding inhibitor on photolysis at 366 nm.",

author = "Woodrell, {Christopher D.} and Kehayova, {Polina D.} and Ahamindra Jain",

year = "1999",

month = aug,

day = "26",

doi = "10.1021/ol9907062",

language = "English",

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journal = "Organic Letters",

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T1 - Photochemically-triggered decarboxylation/deamination of o-nitrodimethoxyphenylglycine

AU - Woodrell, Christopher D.

AU - Kehayova, Polina D.

AU - Jain, Ahamindra

PY - 1999/8/26

Y1 - 1999/8/26

N2 - (Matrix presented) o-Nitrodimethoxyphenylglycine (1) decomposes on photolysis at 366 nm to release ammonia and carbon dioxide, via a five-step mechanism (Scheme 1). We have obtained spectroscopic and kinetic data from experiment and calculation which support our mechanism. We have also confirmed that a carbonic anhydrase inhibitor bearing 1 as a photolabile cage releases a tight-binding inhibitor on photolysis at 366 nm.

AB - (Matrix presented) o-Nitrodimethoxyphenylglycine (1) decomposes on photolysis at 366 nm to release ammonia and carbon dioxide, via a five-step mechanism (Scheme 1). We have obtained spectroscopic and kinetic data from experiment and calculation which support our mechanism. We have also confirmed that a carbonic anhydrase inhibitor bearing 1 as a photolabile cage releases a tight-binding inhibitor on photolysis at 366 nm.

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U2 - 10.1021/ol9907062

DO - 10.1021/ol9907062

M3 - Article

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JO - Organic Letters

JF - Organic Letters

IS - 4

ER -

Photochemically-triggered decarboxylation/deamination of o-nitrodimethoxyphenylglycine

Abstract

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