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Photochemical preparation of a novel low molecular weight heparin
Kyohei Higashi
, Saori Hosoyama
, Asami Ohno
, Sayaka Masuko
, Bo Yang
, Eric Sterner
, Zhenyu Wang
, Robert J. Linhardt
, Toshihiko Toida
Research output
:
Contribution to journal
›
Article
›
peer-review
44
Scopus citations
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Keyphrases
Low Molecular Weight Heparin
100%
Photochemical Preparation
100%
Polysaccharide
40%
Unfractionated Heparin
40%
Photochemical Reaction
40%
Rutile
40%
Saccharides
40%
Liquid Chromatography-tandem Mass Spectrometry (LC-MS/MS)
20%
Photolysis
20%
Anticoagulant Activity
20%
Filtration
20%
Enoxaparin
20%
Commercially Available
20%
Reduced Length
20%
Centrifugation
20%
1H NMR Spectra
20%
Dalteparin
20%
Pure Product
20%
Product Quality
20%
Reaction Conditions
20%
Product Yield
20%
Side Reactions
20%
Enzymatic Elimination
20%
Strong Reaction
20%
Peroxidative
20%
Core Structure
20%
Nitrous Acid
20%
Acid Cleavage
20%
Chemistry
Low Molecular Weight Heparin
100%
Titanium Dioxide
60%
Heparin
40%
Photochemical Reaction
40%
Polysaccharide
40%
Anticoagulant
20%
1H NMR Spectrum
20%
Liquid Chromatography Mass Spectrometry (LCMS)
20%
Photolysis
20%
Nitrous Acid
20%
Centrifugation
20%
Chemical Engineering
Titanium Dioxide
100%
Polysaccharide
66%
Photochemical Reaction
66%
Centrifugation
33%
Liquid Chromatography Mass Spectrometry
33%
Biochemistry, Genetics and Molecular Biology
Molecular Weight
100%
Heparin
100%
Polysaccharide
28%
Liquid Chromatography-Mass Spectrometry
14%
Anticoagulation
14%
Centrifugation
14%
Photolysis
14%