Phospholipase Cγ in distinct regions of the ventral tegmental area differentially regulates morphine-induced locomotor activity

Carlos A. Bolaños, Rachael L. Neve, Eric J. Nestler

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Neurotrophic factors and the signaling pathways they activate play a role in mediating long-term molecular, cellular, and behavioral adaptations associated with drug addiction. Here we mimicked the biological response of phospholipase C-γ (PLCγ) induction in the ventral tegmental area (VTA) observed after chronic morphine using viral-mediated gene transfer. Using a behavioral sensitization paradigm, we demonstrate that microinjections of PLC-γ1 into distinct (rostral vs. caudal) regions of the VTA result in differential locomotor responses to morphine.

Original languageEnglish
Pages (from-to)166-169
Number of pages4
JournalSynapse
Volume56
Issue number3
DOIs
StatePublished - 1 Jun 2005
Externally publishedYes

Keywords

  • Behavioral sensitization
  • Drug addiction
  • Growth factors
  • Morphine
  • Neural plasticity
  • Viral-mediated gene transfer

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