Phosphoinositide regulation of non-canonical transient receptor potential channels

Tibor Rohacs

doi:10.1016/j.ceca.2009.03.011

Phosphoinositide regulation of non-canonical transient receptor potential channels

Tibor Rohacs

Research output: Contribution to journal › Review article › peer-review

68 Scopus citations

Abstract

Transient receptor potential (TRP) channels are involved in a wide range of physiological processes, and characterized by diverse activation mechanisms. Phosphoinositides, especially phosphatidylinositol 4,5-bisphosphate [PIP₂, or PtdIns(4,5)P₂] recently emerged as regulators of many TRP channels. Several TRP channels require PIP₂ for activity, and depletion of the lipid inhibits them. For some TRP channels, however, phosphoinositide regulation seems more complex, both activating and inhibitory effects have been reported. This review will discuss phosphoinositide regulation of members of the TRPM (Melastatin), TRPV (Vanilloid), TRPA (Ankyrin) and TRPP (Polycystin) families. Lipid regulation of TRPC (Canonical) channels is discussed elsewhere in this volume.

Original language	English
Pages (from-to)	554-565
Number of pages	12
Journal	Cell Calcium
Volume	45
Issue number	6
DOIs	https://doi.org/10.1016/j.ceca.2009.03.011
State	Published - Jun 2009
Externally published	Yes

Keywords

PIP
Phosphoinositides
TRP channels

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10.1016/j.ceca.2009.03.011

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title = "Phosphoinositide regulation of non-canonical transient receptor potential channels",

abstract = "Transient receptor potential (TRP) channels are involved in a wide range of physiological processes, and characterized by diverse activation mechanisms. Phosphoinositides, especially phosphatidylinositol 4,5-bisphosphate [PIP2, or PtdIns(4,5)P2] recently emerged as regulators of many TRP channels. Several TRP channels require PIP2 for activity, and depletion of the lipid inhibits them. For some TRP channels, however, phosphoinositide regulation seems more complex, both activating and inhibitory effects have been reported. This review will discuss phosphoinositide regulation of members of the TRPM (Melastatin), TRPV (Vanilloid), TRPA (Ankyrin) and TRPP (Polycystin) families. Lipid regulation of TRPC (Canonical) channels is discussed elsewhere in this volume.",

keywords = "PIP, Phosphoinositides, TRP channels",

author = "Tibor Rohacs",

note = "Funding Information: I thank all members of my laboratory for discussions and Dr. Martha Nowycky for helpful comments on the manuscript. The work in the author's laboratory was supported by the Alexander and Alexandrine Sinsheimer Foundation, the UMDNJ Foundation and the National Institutes of Health Grant NS055159. ",

year = "2009",

month = jun,

doi = "10.1016/j.ceca.2009.03.011",

language = "English",

volume = "45",

pages = "554--565",

journal = "Cell Calcium",

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publisher = "Elsevier Ltd.",

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T1 - Phosphoinositide regulation of non-canonical transient receptor potential channels

AU - Rohacs, Tibor

N1 - Funding Information: I thank all members of my laboratory for discussions and Dr. Martha Nowycky for helpful comments on the manuscript. The work in the author's laboratory was supported by the Alexander and Alexandrine Sinsheimer Foundation, the UMDNJ Foundation and the National Institutes of Health Grant NS055159.

PY - 2009/6

Y1 - 2009/6

N2 - Transient receptor potential (TRP) channels are involved in a wide range of physiological processes, and characterized by diverse activation mechanisms. Phosphoinositides, especially phosphatidylinositol 4,5-bisphosphate [PIP2, or PtdIns(4,5)P2] recently emerged as regulators of many TRP channels. Several TRP channels require PIP2 for activity, and depletion of the lipid inhibits them. For some TRP channels, however, phosphoinositide regulation seems more complex, both activating and inhibitory effects have been reported. This review will discuss phosphoinositide regulation of members of the TRPM (Melastatin), TRPV (Vanilloid), TRPA (Ankyrin) and TRPP (Polycystin) families. Lipid regulation of TRPC (Canonical) channels is discussed elsewhere in this volume.

AB - Transient receptor potential (TRP) channels are involved in a wide range of physiological processes, and characterized by diverse activation mechanisms. Phosphoinositides, especially phosphatidylinositol 4,5-bisphosphate [PIP2, or PtdIns(4,5)P2] recently emerged as regulators of many TRP channels. Several TRP channels require PIP2 for activity, and depletion of the lipid inhibits them. For some TRP channels, however, phosphoinositide regulation seems more complex, both activating and inhibitory effects have been reported. This review will discuss phosphoinositide regulation of members of the TRPM (Melastatin), TRPV (Vanilloid), TRPA (Ankyrin) and TRPP (Polycystin) families. Lipid regulation of TRPC (Canonical) channels is discussed elsewhere in this volume.

KW - PIP

KW - Phosphoinositides

KW - TRP channels

UR - https://www.scopus.com/pages/publications/67349183758

U2 - 10.1016/j.ceca.2009.03.011

DO - 10.1016/j.ceca.2009.03.011

M3 - Review article

C2 - 19376575

AN - SCOPUS:67349183758

SN - 0143-4160

VL - 45

SP - 554

EP - 565

JO - Cell Calcium

JF - Cell Calcium

IS - 6

ER -

Phosphoinositide regulation of non-canonical transient receptor potential channels

Abstract

Keywords

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