TY - JOUR
T1 - Phosphatidylinositol 3-kinase, growth disorders, and cancer
AU - Goncalves, Marcus D.
AU - Hopkins, Benjamin D.
AU - Cantley, Lewis C.
N1 - Publisher Copyright:
Copyright © 2018 Massachusetts Medical Society.
PY - 2018/11/22
Y1 - 2018/11/22
N2 - PI3K is a key regulatory node in growth-factor signaling across evolution. Its importance in a wide array of physiologic processes, including insulin signaling, cell growth, immunity, and brain development, has been confirmed in animal models and humans. In particular, PI3K has held great promise as an anticancer target from the time of its initial discovery. Multiple targeted agents are now available, and we expect that they will be proved effective when coupled with strategies to minimize insulin feedback.
AB - PI3K is a key regulatory node in growth-factor signaling across evolution. Its importance in a wide array of physiologic processes, including insulin signaling, cell growth, immunity, and brain development, has been confirmed in animal models and humans. In particular, PI3K has held great promise as an anticancer target from the time of its initial discovery. Multiple targeted agents are now available, and we expect that they will be proved effective when coupled with strategies to minimize insulin feedback.
UR - http://www.scopus.com/inward/record.url?scp=85056929694&partnerID=8YFLogxK
U2 - 10.1056/NEJMra1704560
DO - 10.1056/NEJMra1704560
M3 - Article
C2 - 30462943
AN - SCOPUS:85056929694
SN - 0028-4793
VL - 379
SP - 2052
EP - 2062
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 21
ER -