Phenytoin intoxication

John M. Murphy, Rajeev Motiwala, Orrin Devinsky

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

We studied the clinical features of 85 cases of phenytoin toxicity in 76 patients treated at a general hospital. Serum levels of phenytoin on admission ranged from 30.3 to 95.0 µg/mL (median, 46.5). Iatrogenic causes of intoxication were common and included increased daily dosage and intravenous loading in the emergency room for single seizures in patients with subtherapeutic serum phenytoin levels. The most frequent neurologic findings were nystagmus (95%), ataxia (88%), lethargy (22%), and seizures (19%). Outcome was usually good, but three patients had serious complications.

Original languageEnglish
Pages (from-to)1199-1204
Number of pages6
JournalSouthern Medical Journal
Volume84
Issue number10
DOIs
StatePublished - Oct 1991
Externally publishedYes

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