Phenotypic changes induced in the human thymic all cell line HPB-all by an ingenol ester, milliamin

Yoshinobu Nakao; Toshimitsu Matsui; Shuichi Matsuda; Shunichi Shiozawa; Takuo Fujita; Yohei Ito

doi:10.1016/0192-0561(83)90021-8

Phenotypic changes induced in the human thymic all cell line HPB-all by an ingenol ester, milliamin

Yoshinobu Nakao
, Toshimitsu Matsui
, Shuichi Matsuda
, Shunichi Shiozawa
, Takuo Fujita
, Yohei Ito

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

An ingenol ester, milliamin, induced phenotypic changes in human thymic ALL cell line HPB-ALL. These alterations included morphological changes, increased sRBC-rosetting, the induction of phenotypic changes of differentiation antigens, i.e. a decrease in OKT4-, OKT6-, OKT9-, OKT10- and Leu31-positive cells and an increase in Leu2a-positive cells, growth inhibition and decreased DNA synthesis. These phenotypic changes were qualitatively and quantitatively similar to those induced by other polyol diterpens with tigliane and daphnane hydrocarbon skeletons such as TPA and mezereine, respectively.

Original language	English
Pages (from-to)	443-453
Number of pages	11
Journal	International Journal of Immunopharmacology
Volume	5
Issue number	5
DOIs	https://doi.org/10.1016/0192-0561(83)90021-8
State	Published - 1983
Externally published	Yes

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@article{c41865d6f7da4343ba8111972f43927d,

title = "Phenotypic changes induced in the human thymic all cell line HPB-all by an ingenol ester, milliamin",

abstract = "An ingenol ester, milliamin, induced phenotypic changes in human thymic ALL cell line HPB-ALL. These alterations included morphological changes, increased sRBC-rosetting, the induction of phenotypic changes of differentiation antigens, i.e. a decrease in OKT4-, OKT6-, OKT9-, OKT10- and Leu31-positive cells and an increase in Leu2a-positive cells, growth inhibition and decreased DNA synthesis. These phenotypic changes were qualitatively and quantitatively similar to those induced by other polyol diterpens with tigliane and daphnane hydrocarbon skeletons such as TPA and mezereine, respectively.",

author = "Yoshinobu Nakao and Toshimitsu Matsui and Shuichi Matsuda and Shunichi Shiozawa and Takuo Fujita and Yohei Ito",

note = "Funding Information: :1: To whom all correspondence should be addressed. This work was supported in part by a Grant-in-Aid for Cancer Research from the Ministry of Education, Science and Culture of Japan.",

year = "1983",

doi = "10.1016/0192-0561(83)90021-8",

language = "English",

volume = "5",

pages = "443--453",

journal = "International Journal of Immunopharmacology",

issn = "0192-0561",

publisher = "Elsevier B.V.",

number = "5",

}

TY - JOUR

T1 - Phenotypic changes induced in the human thymic all cell line HPB-all by an ingenol ester, milliamin

AU - Nakao, Yoshinobu

AU - Matsui, Toshimitsu

AU - Matsuda, Shuichi

AU - Shiozawa, Shunichi

AU - Fujita, Takuo

AU - Ito, Yohei

N1 - Funding Information: :1: To whom all correspondence should be addressed. This work was supported in part by a Grant-in-Aid for Cancer Research from the Ministry of Education, Science and Culture of Japan.

PY - 1983

Y1 - 1983

N2 - An ingenol ester, milliamin, induced phenotypic changes in human thymic ALL cell line HPB-ALL. These alterations included morphological changes, increased sRBC-rosetting, the induction of phenotypic changes of differentiation antigens, i.e. a decrease in OKT4-, OKT6-, OKT9-, OKT10- and Leu31-positive cells and an increase in Leu2a-positive cells, growth inhibition and decreased DNA synthesis. These phenotypic changes were qualitatively and quantitatively similar to those induced by other polyol diterpens with tigliane and daphnane hydrocarbon skeletons such as TPA and mezereine, respectively.

AB - An ingenol ester, milliamin, induced phenotypic changes in human thymic ALL cell line HPB-ALL. These alterations included morphological changes, increased sRBC-rosetting, the induction of phenotypic changes of differentiation antigens, i.e. a decrease in OKT4-, OKT6-, OKT9-, OKT10- and Leu31-positive cells and an increase in Leu2a-positive cells, growth inhibition and decreased DNA synthesis. These phenotypic changes were qualitatively and quantitatively similar to those induced by other polyol diterpens with tigliane and daphnane hydrocarbon skeletons such as TPA and mezereine, respectively.

UR - https://www.scopus.com/pages/publications/0021082434

U2 - 10.1016/0192-0561(83)90021-8

DO - 10.1016/0192-0561(83)90021-8

M3 - Article

C2 - 6581139

AN - SCOPUS:0021082434

SN - 0192-0561

VL - 5

SP - 443

EP - 453

JO - International Journal of Immunopharmacology

JF - International Journal of Immunopharmacology

IS - 5

ER -

Phenotypic changes induced in the human thymic all cell line HPB-all by an ingenol ester, milliamin

Abstract

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