Phencyclidine-induced rotation and hippocampal modulation of nigrostriatal asymmetry

Stanley D. Glick; Richard C. Meibach; Russell D. Cox; Saul Maayani

doi:10.1016/0006-8993(80)90719-2

Phencyclidine-induced rotation and hippocampal modulation of nigrostriatal asymmetry

Stanley D. Glick, Richard C. Meibach, Russell D. Cox, Saul Maayani

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Phencyclidine (PCP) elicited dose-related rotation in naive rats. The effect of PCP was consistent in direction and magnitude from one week to the next but was dissimilar to the rotatory effects of dopaminergic (D-amphetamine, apomorphine) or anticholinergic (scopolamine) drugs. Study of the effects of PCP on regional brain uptake of labeled 2-deoxy-D-glucose suggested that PCP-induced rotation is at least in part mediated by an action in the hippocampus. PCP elicited ipsilateral rotation following unilateral hippocampal lesions whereas such lesions did not alter the direction of either nocturnal orD-amphetamine-induced rotation. PCP appears to activate a hippocampal mechanism that normally only modulates the intensity of rotation.

Original language	English
Pages (from-to)	99-107
Number of pages	9
Journal	Brain Research
Volume	196
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(80)90719-2
State	Published - 25 Aug 1980
Externally published	Yes

Keywords

D-amphetamine
caudate
circling behavior
hippocampus
nigrostriatal
phencyclidine
rotation

Access to Document

10.1016/0006-8993(80)90719-2

Cite this

@article{b40dc1ceb7fc47fabb4faed292892784,

title = "Phencyclidine-induced rotation and hippocampal modulation of nigrostriatal asymmetry",

abstract = "Phencyclidine (PCP) elicited dose-related rotation in naive rats. The effect of PCP was consistent in direction and magnitude from one week to the next but was dissimilar to the rotatory effects of dopaminergic (D-amphetamine, apomorphine) or anticholinergic (scopolamine) drugs. Study of the effects of PCP on regional brain uptake of labeled 2-deoxy-D-glucose suggested that PCP-induced rotation is at least in part mediated by an action in the hippocampus. PCP elicited ipsilateral rotation following unilateral hippocampal lesions whereas such lesions did not alter the direction of either nocturnal orD-amphetamine-induced rotation. PCP appears to activate a hippocampal mechanism that normally only modulates the intensity of rotation.",

keywords = "D-amphetamine, caudate, circling behavior, hippocampus, nigrostriatal, phencyclidine, rotation",

author = "Glick, {Stanley D.} and Meibach, {Richard C.} and Cox, {Russell D.} and Saul Maayani",

year = "1980",

month = aug,

day = "25",

doi = "10.1016/0006-8993(80)90719-2",

language = "English",

volume = "196",

pages = "99--107",

journal = "Brain Research",

issn = "0006-8993",

publisher = "Elsevier B.V.",

number = "1",

}

TY - JOUR

T1 - Phencyclidine-induced rotation and hippocampal modulation of nigrostriatal asymmetry

AU - Glick, Stanley D.

AU - Meibach, Richard C.

AU - Cox, Russell D.

AU - Maayani, Saul

PY - 1980/8/25

Y1 - 1980/8/25

N2 - Phencyclidine (PCP) elicited dose-related rotation in naive rats. The effect of PCP was consistent in direction and magnitude from one week to the next but was dissimilar to the rotatory effects of dopaminergic (D-amphetamine, apomorphine) or anticholinergic (scopolamine) drugs. Study of the effects of PCP on regional brain uptake of labeled 2-deoxy-D-glucose suggested that PCP-induced rotation is at least in part mediated by an action in the hippocampus. PCP elicited ipsilateral rotation following unilateral hippocampal lesions whereas such lesions did not alter the direction of either nocturnal orD-amphetamine-induced rotation. PCP appears to activate a hippocampal mechanism that normally only modulates the intensity of rotation.

AB - Phencyclidine (PCP) elicited dose-related rotation in naive rats. The effect of PCP was consistent in direction and magnitude from one week to the next but was dissimilar to the rotatory effects of dopaminergic (D-amphetamine, apomorphine) or anticholinergic (scopolamine) drugs. Study of the effects of PCP on regional brain uptake of labeled 2-deoxy-D-glucose suggested that PCP-induced rotation is at least in part mediated by an action in the hippocampus. PCP elicited ipsilateral rotation following unilateral hippocampal lesions whereas such lesions did not alter the direction of either nocturnal orD-amphetamine-induced rotation. PCP appears to activate a hippocampal mechanism that normally only modulates the intensity of rotation.

KW - D-amphetamine

KW - caudate

KW - circling behavior

KW - hippocampus

KW - nigrostriatal

KW - phencyclidine

KW - rotation

UR - http://www.scopus.com/inward/record.url?scp=0018959087&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(80)90719-2

DO - 10.1016/0006-8993(80)90719-2

M3 - Article

C2 - 7190455

AN - SCOPUS:0018959087

SN - 0006-8993

VL - 196

SP - 99

EP - 107

JO - Brain Research

JF - Brain Research

IS - 1

ER -

Phencyclidine-induced rotation and hippocampal modulation of nigrostriatal asymmetry

Abstract

Keywords

Access to Document

Fingerprint

Cite this