TY - JOUR
T1 - Phase II Randomized Study of Concomitant Chemoradiation Using Weekly Carboplatin/Paclitaxel with or without Daily Subcutaneous Amifostine in Patients with Newly Diagnosed Locally Advanced Squamous Cell Carcinoma of the Head and Neck
AU - Haddad, Robert
AU - Wirth, Lori
AU - Costello, Rosemary
AU - Weeks, Linda
AU - Posner, Marshall
PY - 2003/12
Y1 - 2003/12
N2 - The treatment of head and neck cancer continues to evolve. The recent use of aggressive chemoradiotherapy protocols has resulted in significant morbidity involving mucositis, dysphagia, and a higher rate of feeding tube dependency. We have initiated a randomized phase II study with concomitant chemoradiotherapy with or without subcutaneous amifostine (Ethyol, WR-2721; MedImmune, Inc, Gaithersburg, MD). This article presents a detailed background, rationale, and endpoints for this study and discusses future directions in the treatment of head and neck cancer.
AB - The treatment of head and neck cancer continues to evolve. The recent use of aggressive chemoradiotherapy protocols has resulted in significant morbidity involving mucositis, dysphagia, and a higher rate of feeding tube dependency. We have initiated a randomized phase II study with concomitant chemoradiotherapy with or without subcutaneous amifostine (Ethyol, WR-2721; MedImmune, Inc, Gaithersburg, MD). This article presents a detailed background, rationale, and endpoints for this study and discusses future directions in the treatment of head and neck cancer.
UR - http://www.scopus.com/inward/record.url?scp=1642435541&partnerID=8YFLogxK
U2 - 10.1053/j.seminoncol.2003.11.011
DO - 10.1053/j.seminoncol.2003.11.011
M3 - Article
C2 - 14727246
AN - SCOPUS:1642435541
SN - 0093-7754
VL - 30
SP - 84
EP - 88
JO - Seminars in Oncology
JF - Seminars in Oncology
IS - 6 SUPPL. 18
ER -