PharmVar GeneFocus: CYP2C19

Mariana R. Botton; Michelle Whirl-Carrillo; Andria L. Del Tredici; Katrin Sangkuhl; Larisa H. Cavallari; José A.G. Agúndez; Jorge Duconge; Ming Ta Michael Lee; Erica L. Woodahl; Karla Claudio-Campos; Ann K. Daly; Teri E. Klein; Victoria M. Pratt; Stuart A. Scott; Andrea Gaedigk

doi:10.1002/cpt.1973

PharmVar GeneFocus: CYP2C19

Mariana R. Botton, Michelle Whirl-Carrillo, Andria L. Del Tredici, Katrin Sangkuhl, Larisa H. Cavallari, José A.G. Agúndez, Jorge Duconge, Ming Ta Michael Lee, Erica L. Woodahl, Karla Claudio-Campos, Ann K. Daly, Teri E. Klein, Victoria M. Pratt, Stuart A. Scott, Andrea Gaedigk

Research output: Contribution to journal › Review article › peer-review

99 Scopus citations

Abstract

The Pharmacogene Variation Consortium (PharmVar) catalogues star (*) allele nomenclature for the polymorphic human CYP2C19 gene. CYP2C19 genetic variation impacts the metabolism of many drugs and has been associated with both efficacy and safety issues for several commonly prescribed medications. This GeneFocus provides a comprehensive overview and summary of CYP2C19 and describes how haplotype information catalogued by PharmVar is utilized by the Pharmacogenomics Knowledgebase and the Clinical Pharmacogenetics Implementation Consortium (CPIC).

Original language	English
Pages (from-to)	352-366
Number of pages	15
Journal	Clinical Pharmacology and Therapeutics
Volume	109
Issue number	2
DOIs	https://doi.org/10.1002/cpt.1973
State	Published - Feb 2021

Access to Document

10.1002/cpt.1973

Cite this

@article{6f6eca27188b4a1c8c03905b51a8d30f,

title = "PharmVar GeneFocus: CYP2C19",

abstract = "The Pharmacogene Variation Consortium (PharmVar) catalogues star (*) allele nomenclature for the polymorphic human CYP2C19 gene. CYP2C19 genetic variation impacts the metabolism of many drugs and has been associated with both efficacy and safety issues for several commonly prescribed medications. This GeneFocus provides a comprehensive overview and summary of CYP2C19 and describes how haplotype information catalogued by PharmVar is utilized by the Pharmacogenomics Knowledgebase and the Clinical Pharmacogenetics Implementation Consortium (CPIC).",

author = "Botton, {Mariana R.} and Michelle Whirl-Carrillo and {Del Tredici}, {Andria L.} and Katrin Sangkuhl and Cavallari, {Larisa H.} and Ag{\'u}ndez, {Jos{\'e} A.G.} and Jorge Duconge and Lee, {Ming Ta Michael} and Woodahl, {Erica L.} and Karla Claudio-Campos and Daly, {Ann K.} and Klein, {Teri E.} and Pratt, {Victoria M.} and Scott, {Stuart A.} and Andrea Gaedigk",

note = "Publisher Copyright: {\textcopyright} 2020 The Author. Clinical Pharmacology & Therapeutics published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics.",

year = "2021",

month = feb,

doi = "10.1002/cpt.1973",

language = "English",

volume = "109",

pages = "352--366",

journal = "Clinical Pharmacology and Therapeutics",

issn = "0009-9236",

publisher = "Wiley-Blackwell",

number = "2",

}

TY - JOUR

T1 - PharmVar GeneFocus

T2 - CYP2C19

AU - Botton, Mariana R.

AU - Whirl-Carrillo, Michelle

AU - Del Tredici, Andria L.

AU - Sangkuhl, Katrin

AU - Cavallari, Larisa H.

AU - Agúndez, José A.G.

AU - Duconge, Jorge

AU - Lee, Ming Ta Michael

AU - Woodahl, Erica L.

AU - Claudio-Campos, Karla

AU - Daly, Ann K.

AU - Klein, Teri E.

AU - Pratt, Victoria M.

AU - Scott, Stuart A.

AU - Gaedigk, Andrea

PY - 2021/2

Y1 - 2021/2

N2 - The Pharmacogene Variation Consortium (PharmVar) catalogues star (*) allele nomenclature for the polymorphic human CYP2C19 gene. CYP2C19 genetic variation impacts the metabolism of many drugs and has been associated with both efficacy and safety issues for several commonly prescribed medications. This GeneFocus provides a comprehensive overview and summary of CYP2C19 and describes how haplotype information catalogued by PharmVar is utilized by the Pharmacogenomics Knowledgebase and the Clinical Pharmacogenetics Implementation Consortium (CPIC).

AB - The Pharmacogene Variation Consortium (PharmVar) catalogues star (*) allele nomenclature for the polymorphic human CYP2C19 gene. CYP2C19 genetic variation impacts the metabolism of many drugs and has been associated with both efficacy and safety issues for several commonly prescribed medications. This GeneFocus provides a comprehensive overview and summary of CYP2C19 and describes how haplotype information catalogued by PharmVar is utilized by the Pharmacogenomics Knowledgebase and the Clinical Pharmacogenetics Implementation Consortium (CPIC).

UR - http://www.scopus.com/inward/record.url?scp=85076737968&partnerID=8YFLogxK

U2 - 10.1002/cpt.1973

DO - 10.1002/cpt.1973

M3 - Review article

C2 - 32602114

AN - SCOPUS:85076737968

SN - 0009-9236

VL - 109

SP - 352

EP - 366

JO - Clinical Pharmacology and Therapeutics

JF - Clinical Pharmacology and Therapeutics

IS - 2

ER -

PharmVar GeneFocus: CYP2C19

Abstract

Access to Document

Fingerprint

Cite this