@article{6f6eca27188b4a1c8c03905b51a8d30f,
title = "PharmVar GeneFocus: CYP2C19",
abstract = "The Pharmacogene Variation Consortium (PharmVar) catalogues star (*) allele nomenclature for the polymorphic human CYP2C19 gene. CYP2C19 genetic variation impacts the metabolism of many drugs and has been associated with both efficacy and safety issues for several commonly prescribed medications. This GeneFocus provides a comprehensive overview and summary of CYP2C19 and describes how haplotype information catalogued by PharmVar is utilized by the Pharmacogenomics Knowledgebase and the Clinical Pharmacogenetics Implementation Consortium (CPIC).",
author = "Botton, {Mariana R.} and Michelle Whirl-Carrillo and {Del Tredici}, {Andria L.} and Katrin Sangkuhl and Cavallari, {Larisa H.} and Ag{\'u}ndez, {Jos{\'e} A.G.} and Jorge Duconge and Lee, {Ming Ta Michael} and Woodahl, {Erica L.} and Karla Claudio-Campos and Daly, {Ann K.} and Klein, {Teri E.} and Pratt, {Victoria M.} and Scott, {Stuart A.} and Andrea Gaedigk",
note = "Funding Information: This work was funded by the National Institutes of Health for the Pharmacogene Variation Consortium (R24 GM123930; P.I., A.G.) and PharmGKB (U24 HG010615; P.I., T.E.K.). V.M.P. is supported by the Implementing Genomics in Practice (IGNITE) project grant (U01 HG010245). J.D. is supported by grant U54 MD007600-33 (RCMI Program) from NIH/NIMHD. The authors thank Dr Mia Wadelius, Uppsala University, Sweden, for serving on the PharmVar CYP2C expert panel since its inception and critical comments on the manuscript. We also like to sincerely thank Dr Roger Gaedigk for his assistance with graphical artwork and critically reading the manuscript. Funding Information: This work was funded by the National Institutes of Health for the Pharmacogene Variation Consortium (R24 GM123930; P.I., A.G.) and PharmGKB (U24 HG010615; P.I., T.E.K.). V.M.P. is supported by the Implementing Genomics in Practice (IGNITE) project grant (U01 HG010245). J.D. is supported by grant U54 MD007600‐33 (RCMI Program) from NIH/NIMHD. Publisher Copyright: {\textcopyright} 2020 The Author. Clinical Pharmacology & Therapeutics published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics.",
year = "2021",
month = feb,
doi = "10.1002/cpt.1973",
language = "English",
volume = "109",
pages = "352--366",
journal = "Clinical Pharmacology and Therapeutics",
issn = "0009-9236",
publisher = "Wiley-Blackwell",
number = "2",
}