Pharmacological studies with cefamandole in human volunteers

B. R. Meyers, B. Ribner, S. Yancovitz, S. Z. Hirschman

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Serum and urine concentrations were measured after administration of 0.5 and 1 g doses of cefamandole intramuscularly and intravenously to healthy volunteers. Intramuscular doses of 0.5 and 1 g yielded serum concentrations at 1 h of 14.7 and 35.6 μg/ml, respectively. Significant antibacterial concentrations persisted through h 8. Intravenous doses of 0.5 and 1 g resulted in respective peak serum levels of 21 μg/ml at 45 min and 103 μg/ml at 15 min; these serum levels rapidly declined. Very high urine concentrations were achieved during the first 8 h after injection.

Original languageEnglish
Pages (from-to)140-144
Number of pages5
JournalAntimicrobial Agents and Chemotherapy
Volume9
Issue number1
DOIs
StatePublished - 1976
Externally publishedYes

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