TY - JOUR
T1 - Pharmacological modulation of astrocytes and the role of cell type-specific histone modifications for the treatment of mood disorders
AU - Jakovcevski, Mira
AU - Akbarian, Schahram
AU - Di Benedetto, Barbara
N1 - Funding Information:
The work of MJ is supported by a Marie Curie Intra European Fellowship within the 7 th European Community Framework Programme and by the NARSAD Young investigator grant from the Brain and Behavior Research Foundation (in cooperation with AS). The work of BDB is supported by intramural funding from the University of Regensburg and by the German Federal Ministry of Education and Research (BMBF). The sponsors did not have any role in the collection, analysis and interpretation of data, in the writing of the report and in the decision to submit the article for publication.
Publisher Copyright:
© 2015 Elsevier Ltd.
PY - 2016/2
Y1 - 2016/2
N2 - Astrocytes orchestrate arrangement and functions of neuronal circuits and of the blood-brain barrier. Dysfunctional astrocytes characterize mood disorders, here showcased by deregulation of the astrocyte end-feet protein Aquaporin-4 around blood vessels and, hypothetically, of the astrocyte-specific phagocytic protein MEGF10 to shape synapses. Development of mood disorders is often a result of 'gene × environment' interactions, regulated among others by histone modifications and related modulator enzymes, which rapidly promote adaptive responses. Thus, they represent ideal targets of drugs aimed at inducing stable effects with quick onsets. One of the prevalent features of histone modifications and their modulators is their cell-type specificity. Investigating cell type-specific epigenetic modulations upon drug administration might therefore help to implement therapeutic treatments.
AB - Astrocytes orchestrate arrangement and functions of neuronal circuits and of the blood-brain barrier. Dysfunctional astrocytes characterize mood disorders, here showcased by deregulation of the astrocyte end-feet protein Aquaporin-4 around blood vessels and, hypothetically, of the astrocyte-specific phagocytic protein MEGF10 to shape synapses. Development of mood disorders is often a result of 'gene × environment' interactions, regulated among others by histone modifications and related modulator enzymes, which rapidly promote adaptive responses. Thus, they represent ideal targets of drugs aimed at inducing stable effects with quick onsets. One of the prevalent features of histone modifications and their modulators is their cell-type specificity. Investigating cell type-specific epigenetic modulations upon drug administration might therefore help to implement therapeutic treatments.
UR - http://www.scopus.com/inward/record.url?scp=84944810498&partnerID=8YFLogxK
U2 - 10.1016/j.coph.2015.10.002
DO - 10.1016/j.coph.2015.10.002
M3 - Review article
C2 - 26515273
AN - SCOPUS:84944810498
SN - 1471-4892
VL - 26
SP - 61
EP - 66
JO - Current Opinion in Pharmacology
JF - Current Opinion in Pharmacology
ER -