Pharmacological Inhibition of Exosome Machinery: An Emerging Prospect in Cancer Therapeutics

Saima Syeda, Kavita Rawat, Anju Shrivastava

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Exosomes are nanocarriers that mediate intercellular communication crucial for normal physiological functions. However, exponentially emerging reports have correlated their dysregulated release with various pathologies, including cancer. In cancer, from stromal remodeling to metastasis, where tumor cells bypass the immune surveillance and show drug resistivity, it has been established to be mediated via tumor-derived exosomes. Owing to their role in cancer pathogenicity, exosome-based strategies offer enormous potential in treatment regimens. These strategies include the use of exosomes as a drug carrier or as an immunotherapeutic agent, which requires advanced nanotechnol-ogies for exosome isolation and characterization. In contrast, pharmacological inhibition of exosome machinery surpasses the requisites of nanotechnology and thus emerges as an essential prospect in cancer therapeutics. In this line, researchers are currently trying to dissect the molecular pathways to reveal the involvement of key regulatory proteins that facilitate the release of tumor-derived exo-somes. Subsequently, screening of various molecules in targeting these proteins, with eventual abatement of exosome-induced cancer pathogenicity, is being done. However, their clinical transla-tion requires more extensive studies. Here, we comprehensively review the molecular mechanisms regulating exosome release in cancer. Moreover, we provide insight into the key findings that highlight the effect of various drugs as exosome blockers, which will add to the route of drug development in cancer management.

Original languageEnglish
Pages (from-to)560-576
Number of pages17
JournalCurrent Cancer Drug Targets
Volume22
Issue number7
DOIs
StatePublished - Aug 2022
Externally publishedYes

Keywords

  • Tumor-derived exosomes
  • cancer therapeutics
  • drug resistivi-ty
  • exosome blockers
  • nanocarriers
  • regulatory proteins

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