Pharmacological Functionalization of Protein-Based Nanorobots as a Novel Tool for Drug Delivery in Cancer

Omid Tavassoly, Iman Tavassoly

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

The delivery of hydrophobic therapeutic agents to tumors is a challenge in the treatment of cancers. Here, we review recent advances in coiled-coil protein origami and discuss a proposed programmable protein origami structure, switchable by a protein kinase A/phosphatase switch, as an example of functionalization for designing future protein nanorobots.

Original languageEnglish
Pages (from-to)1463-1467
Number of pages5
JournalACS Pharmacology and Translational Science
Volume4
Issue number4
DOIs
StatePublished - 13 Aug 2021

Keywords

  • coiled-coil protein origami
  • nanorobot
  • pharmacological functionalization
  • protein kinase A

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