Pharmacologic inactivation of kinase suppressor of ras-1 abrogates ras-mediated pancreatic cancer

H. Rosie Xing, Carlos Cordon-Cardo, Xinzhu Deng, William Tong, Luis Campodonico, Zvi Fuks, Richard Kolesnick

Research output: Contribution to journalArticlepeer-review

52 Scopus citations

Abstract

Inhibition of the kinase suppressor of ras-1 (KSR1) gene by continuous infusion of phosphorothioate antisense oligonucleotides (ODNs) prevented growth of K-Ras-dependent human PANC-1 pancreatic and A549 non-small-cell lung carcinoma xenografts in nude mice, effected regression of established PANC-1 tumors and inhibited A549 lung metastases, all without apparent toxicity. These studies suggest KSR1 antisense ODNs as a treatment for Ras-dependent human malignancies, in particular pancreatic cancer, which lacks effective curative therapy.

Original languageEnglish
Pages (from-to)1267-1268
Number of pages2
JournalNature Medicine
Volume9
Issue number10
DOIs
StatePublished - Oct 2003
Externally publishedYes

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