Abstract
In 31 dogs chronically beta blocked with oral propranolol (12 to 14 mg/kg/day), glucagon (20 μg/kg) and combined dopamine (10 μg/kg/min) and isoproterenol (0.2 μg/kg/min) were given intravenously and tested for hemodynamic efficacy. Dogs were divided into four groups. Basal hemodynamics were obtained in Group I (n = 8) without cardiopulmonary bypass. In Group II (n = 8), hemodynamics were studied after 15 minutes of global ischemia during cardiopulmonary bypass. In Group III (n = 8), hemodynamics were studied after regional ischemia produced by ligation of the proximal left anterior descending coronary artery. In Group IV (n = 7), myocardial oxygen consumption and left ventricular mechanics were studied before and after 1 hour of cardiopulmonary bypass. Our results indicate the following: (1) Dopamine-isoproterenol improves hemodynamics in basal, post-global ischemic, and post-regional ischemic states. Glucagon improves hemodynamics either insignificantly or to a lesser extent than dopamine-isoproterenol. Furthermore, glucagon produces a larger increase in heart rate, which is not desirable. (2) Both dopamine-isoproterenol and glucagon increase myocardial oxygen consumption in comparison with control.
Original language | English |
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Pages (from-to) | 732-742 |
Number of pages | 11 |
Journal | Journal of Thoracic and Cardiovascular Surgery |
Volume | 87 |
Issue number | 5 |
DOIs | |
State | Published - 1984 |