Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcription

Keyphrases

• Apoptosis 100%
• Pharmacologic 100%
• Transcription-independent 66%
• In Cancer 33%
• Cancer Therapy 33%
• Small Molecules 33%
• Estrogen Receptor 33%
• Ligand-binding Domain 33%
• 4-hydroxytamoxifen 33%
• P53 Protein 33%
• Pharmacologic Agents 33%
• Mutant Forms 33%
• P53 Activation 33%
• Macromolecular Synthesis 33%
• Cytochrome c Release 33%
• Steroid Binding 33%
• Bax Translocation 33%
• P53 Modulator 33%
• PRIMA-1 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Protein P53 100%
• Malignant Neoplasm 14%
• Cytochrome C 14%
• Estrogen Receptor 14%
• Afimoxifene 14%