Pharmacokinetics of ritonavir and delavirdine in human immunodeficiency virus-infected patients

Mark J. Shelton, Ross G. Hewitt, John Adamse, Andrew Della-Coletta, Steven Cox, Gene D. Morse

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

To evaluate the pharmacokinetic effect of adding delavirdine mesylate to the antiretroviral regimens of human immunodeficiency virus (HIV)-infected patients stabilized on a full dosage of ritonavir (600 mg every 12 h), 12 HIV-1-infected subjects had delavirdine mesylate (400 mg every 8 h) added to their current antiretroviral regimens for 21 days. Ritonavir pharmacokinetics were evaluated before (day 7) and after (day 28) the addition of delavirdine, and delavirdine pharmacokinetics were evaluated on day 28. The mean values (± standard deviations) for the maximum concentration in serum (Cmax) of ritonavir, the area under the concentration-time curve from 0 to 12 h (AUC0.12), and the minimum concentration in serum (Cmin) of ritonavir before the addition of delavirdine were 14.8 ± 6.7 μM, 94 ± 36 μM · h, and 3.6 ± 2.1 μM, respectively. These same parameters were increased to 24.6 ± 13.9 μM, 154 ± 83 μM · h, and 6.52 ± 4.85 μM, respectively, after the addition of delavirdine (P is <0.05 for all comparisons). Delavirdine pharmacokinetic parameters in the presence of ritonavir included a Cmax of 23 ± 16 μM, an AUC0.8 of 114 ± 75 μM · h, and a Cmin of 9.1 ± 7.5 μM. Therefore, delavirdine increases systemic exposure to ritonavir by 50 to 80% when the drugs are coadministered.

Original languageEnglish
Pages (from-to)1694-1699
Number of pages6
JournalAntimicrobial Agents and Chemotherapy
Volume47
Issue number5
DOIs
StatePublished - 1 May 2003
Externally publishedYes

Fingerprint

Dive into the research topics of 'Pharmacokinetics of ritonavir and delavirdine in human immunodeficiency virus-infected patients'. Together they form a unique fingerprint.

Cite this