OBJECTIVE: To investigate the disposition of floxuridine in patients with trophoblastic tumors. METHODS: 12 patients with trophoblastic tumors were divided into FUDR and FUDR + KSM group. FUDR was administered by an 8-hour infusion. The blood samples were obtained during the infusion and up to 50 min after the infusion. The concentrations of floxuridine in serum were measured by a reverse-phase high-performance liquid chromatography. The pharmacokinetics of floxuridine was assessed by noncompartment and compartment model. RESULTS: The disposition of floxuridine was nonlinear, consistent with a three-compartment model. The metabolite fluorouracil was found after iv administration of floxuridine. CONCLUSION: Floxuridine was eliminated primarily by a dose-dependent process. Such characteristics may be related to unexpected stronger pharmacological effects if increasing the dose or reducing the infusion time.
|Number of pages||5|
|Journal||Chinese Pharmaceutical Journal|
|State||Published - 1 May 2003|
- Trophoblastic tumors