Pharmacokinetics of floxuridine in patients with trophoblastic tumors

Peng Wang, Zhu Zhu, Qiang Fu, Da kui Li

Research output: Contribution to journalArticlepeer-review


OBJECTIVE: To investigate the disposition of floxuridine in patients with trophoblastic tumors. METHODS: 12 patients with trophoblastic tumors were divided into FUDR and FUDR + KSM group. FUDR was administered by an 8-hour infusion. The blood samples were obtained during the infusion and up to 50 min after the infusion. The concentrations of floxuridine in serum were measured by a reverse-phase high-performance liquid chromatography. The pharmacokinetics of floxuridine was assessed by noncompartment and compartment model. RESULTS: The disposition of floxuridine was nonlinear, consistent with a three-compartment model. The metabolite fluorouracil was found after iv administration of floxuridine. CONCLUSION: Floxuridine was eliminated primarily by a dose-dependent process. Such characteristics may be related to unexpected stronger pharmacological effects if increasing the dose or reducing the infusion time.

Original languageEnglish
Pages (from-to)368-372
Number of pages5
JournalChinese Pharmaceutical Journal
Issue number5
StatePublished - 1 May 2003
Externally publishedYes


  • Floxuridine
  • Pharmacokinetics
  • Trophoblastic tumors


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