Pharmacokinetic interactions between protease inhibitors and statins in HIV seronegative volunteers: ACTG study A5047

Carl J. Fichtenbaum, John G. Gerber, Susan L. Rosenkranz, Yoninah Segal, Judith A. Aberg, Terrence Blaschke, Beverly Alston, Fang Fang, Bradley Kosel, Francesca Aweeka

Research output: Contribution to journalArticlepeer-review

301 Scopus citations

Abstract

Objective: Lipid lowering therapy is used increasingly in persons with HIV infection in the absence of safety data or information on drug interactions with antiretroviral agents. The primary objectives of this study were to examine the effects of ritonavir (RTV) plus saquinavir soft-gel (SQVsgc) capsules on the pharmacokinetics of pravastatin, simvastatin, and atorvastatin, and the effect of pravastatin on the pharmacokinetics of nelfinavir (NFV) in order to determine clinically important drug-drug interactions. Design: Randomized, open-label study in healthy, HIV seronegative adults at AIDS Clinical Trials Units across the USA. Methods: Three groups of subjects (arms 1, 2, and 3) received pravastatin, simvastatin or atorvastatin (40 mg daily each) from days 1-4 and 15-18. In these groups, RTV 400 mg and SQVsgc 400 mg twice daily were given from days 4-18. A fourth group (arm 4) received NFV 1250 mg twice daily from days 1-14 with pravastatin 40 mg daily added from days 15-18. Statin and NFV levels were measured by liquid chromatography/tandem mass spectrometry. Results: Fifty-six subjects completed both pharmacokinetic study days. In arms 1-3, the median estimated area under the curves (AUG)0-24 for the statins were: pravastatin (arm 1, n = 13), 151 and 75 ng·h/ml on days 4 and 18 (decline of 50% in presence of RTV/SQVsgc), respectively (P = 0.005); simvastatin (arm 2, n = 14), 1 7 and 548 ng·h/ml on days 4 and 18 (increase of 3059% in the presence of RTV/SQVsgc), respectively (P < 0.001); and total active atorvastatin (arm 3, n = 14), 167 and 289 ng·h/ml on days 4 and 18 (increase of 79% in the presence of RTV/SQVsgc), respectively (P < 0.001). In arm 4, the median estimated AUC0-8 for NFV (24319 versus 26760 ng·h/ml; P=0.58) and its active M8 metabolite (15565 versus 14571 ng·h/m; P=0.63) were not statistically different from day 14 to day 18 (without or with pravastatin). Conclusions: Simvastatin should be avoided and atorvastatin may be used with caution in persons taking RTV and SQVsgc. Dose adjustment of pravastatin may be necessary with concomitant use of RTV and SQVsgc. Pravastatin does not alter the NFV pharmacokinetics, and thus appears to be safe for concomitant use.

Original languageEnglish
Pages (from-to)569-577
Number of pages9
JournalAIDS
Volume16
Issue number4
DOIs
StatePublished - 8 Mar 2002
Externally publishedYes

Keywords

  • Drug interactions
  • HIV infection
  • HMG-CoA reductase inhibitors
  • Protease inhibitors
  • Statins

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