Pharmacokinetic interaction between nevirapine and ethinyl estradiol/norethindrone when administered concurrently to HIV-infected women

Donna Mildvan, Robert Yarrish, Ann Marshak, Herbert W. Hutman, Marita McDonough, Michael Lamson, Patrick Robinson

Research output: Contribution to journalArticlepeer-review

80 Scopus citations

Abstract

Objective: To determine the effects of nevirapine (NVP), a nonnucleoside reverse-transcriptase inhibitor of HIV-1 and P450 inducer, on the pharmacokinetics (PK) of ethinyl estradiol (EE)/norethindrone (NET), a widely used oral contraceptive, and to assess the effects of EE/NET on the steady-state PK of NVP. Methods: Ten HIV-1-infected women underwent intensive PK sampling after single-dose administration of EE/NET (days 0-1). Oral NVP 200 mg once daily (days 2-15), followed by 200 mg twice daily (days 16-29), was added to background potent antiretroviral therapy. On day 30, intensive PK sampling was performed after concurrent administration of NVP 200 mg and a single dose of EE/NET. Results: Concomitant administration of NVP at steady state with EE/NET resulted in a significant (29%) median reduction in the area under the plasma concentration time curve (AUC∞) and a significant reduction in mean residence time (MRT) and half-life (t1/2) of EE. There was a significant (18%) median reduction in the AUC∞ for NET that was not associated with a detectable change in NET Cmax, MRT, or t1/2. Conclusion: Oral contraceptives should not be the primary method of birth control in women of child-bearing potential who are treated with NVP.

Original languageEnglish
Pages (from-to)471-477
Number of pages7
JournalJournal of Acquired Immune Deficiency Syndromes
Volume29
Issue number5
DOIs
StatePublished - 2002
Externally publishedYes

Keywords

  • Ethinyl estradiol
  • Human immunodeficiency virus
  • Nevirapine
  • Norethindrone
  • Oral contraceptives
  • Pharmacokinetic interaction

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