Pharmacogenomics in Cancer Therapeutics

Y. W.Francis Lam, Stuart A. Scott

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations


With increased knowledge of molecular abnormalities in pathways associated with tumorigenesis, drug development within the oncology discipline has over the last decade mostly shifted from nonspecific cytotoxic agents to targeted therapies. Together with their companion diagnostic tests that allow identification of suitable patients for particular therapeutic agents, targeted anticancer therapy usher in a whole new era of precision therapy for patients with specific types of cancer. In addition to somatic mutations within tumors, genetic variabilities in drug response and/or toxicity are also potential factors that could account for differences in response to anticancer drug therapy. In this brief chapter, the role of pharmacogenomics in cancer therapy is presented focusing on some specific applications.

Original languageEnglish
Title of host publicationPharmacogenomics
Subtitle of host publicationChallenges and Opportunities in Therapeutic Implementation
Number of pages10
ISBN (Electronic)9780128126264
StatePublished - 1 Jan 2018


  • Pharmacogenomics
  • Precision oncology
  • Prognostic
  • Targeted therapies
  • predictive biomarkers


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