Pharmacodynamic relationship of pharmacokinetic parameters of maintenance doses of foscarnet and clinical outcome of cytomegalovirus retinitis

M. A. Jacobson; B. Polsky; D. Causey; R. Davis; W. Tong; J. J. O'Donnell; B. D. Kuppermann; M. H. Heinemann; J. Feinberg; P. Lizak; J. G. Gambertoglio; F. T. Aweeka

doi:10.1128/AAC.38.5.1190

Pharmacodynamic relationship of pharmacokinetic parameters of maintenance doses of foscarnet and clinical outcome of cytomegalovirus retinitis

M. A. Jacobson
, B. Polsky
, D. Causey
, R. Davis
, W. Tong
, J. J. O'Donnell
, B. D. Kuppermann
, M. H. Heinemann
, J. Feinberg
, P. Lizak
, J. G. Gambertoglio
, F. T. Aweeka

Research output: Contribution to journal › Comment/debate

8 Scopus citations

Abstract

The pharmacodynamic relationship between a range of foscarnet exposure measurements obtained from studying nine patients receiving ongoing maintenance therapy for cytomegalovirus retinitis and a range of efficacy values (days to retinitis progression) obtained by independent examination of serial retinal photographs from the same nine patients was analyzed. In the resulting proportional hazards models, the foscarnet area under the concentration-time curve approached statistical significance (P = 0.11) as a predictor of decreased risk of retinitis progression.

Original language	English
Pages (from-to)	1190-1193
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	38
Issue number	5
DOIs	https://doi.org/10.1128/AAC.38.5.1190
State	Published - 1994
Externally published	Yes

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10.1128/AAC.38.5.1190

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Jacobson, M. A., Polsky, B., Causey, D., Davis, R., Tong, W., O'Donnell, J. J., Kuppermann, B. D., Heinemann, M. H., Feinberg, J., Lizak, P., Gambertoglio, J. G., & Aweeka, F. T. (1994). Pharmacodynamic relationship of pharmacokinetic parameters of maintenance doses of foscarnet and clinical outcome of cytomegalovirus retinitis. Antimicrobial Agents and Chemotherapy, 38(5), 1190-1193. https://doi.org/10.1128/AAC.38.5.1190

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title = "Pharmacodynamic relationship of pharmacokinetic parameters of maintenance doses of foscarnet and clinical outcome of cytomegalovirus retinitis",

abstract = "The pharmacodynamic relationship between a range of foscarnet exposure measurements obtained from studying nine patients receiving ongoing maintenance therapy for cytomegalovirus retinitis and a range of efficacy values (days to retinitis progression) obtained by independent examination of serial retinal photographs from the same nine patients was analyzed. In the resulting proportional hazards models, the foscarnet area under the concentration-time curve approached statistical significance (P = 0.11) as a predictor of decreased risk of retinitis progression.",

author = "Jacobson, \{M. A.\} and B. Polsky and D. Causey and R. Davis and W. Tong and O'Donnell, \{J. J.\} and Kuppermann, \{B. D.\} and Heinemann, \{M. H.\} and J. Feinberg and P. Lizak and Gambertoglio, \{J. G.\} and Aweeka, \{F. T.\}",

year = "1994",

doi = "10.1128/AAC.38.5.1190",

language = "English",

volume = "38",

pages = "1190--1193",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "5",

}

Jacobson, MA, Polsky, B, Causey, D, Davis, R, Tong, W, O'Donnell, JJ, Kuppermann, BD, Heinemann, MH, Feinberg, J, Lizak, P, Gambertoglio, JG & Aweeka, FT 1994, 'Pharmacodynamic relationship of pharmacokinetic parameters of maintenance doses of foscarnet and clinical outcome of cytomegalovirus retinitis', Antimicrobial Agents and Chemotherapy, vol. 38, no. 5, pp. 1190-1193. https://doi.org/10.1128/AAC.38.5.1190

TY - JOUR

T1 - Pharmacodynamic relationship of pharmacokinetic parameters of maintenance doses of foscarnet and clinical outcome of cytomegalovirus retinitis

AU - Jacobson, M. A.

AU - Polsky, B.

AU - Causey, D.

AU - Davis, R.

AU - Tong, W.

AU - O'Donnell, J. J.

AU - Kuppermann, B. D.

AU - Heinemann, M. H.

AU - Feinberg, J.

AU - Lizak, P.

AU - Gambertoglio, J. G.

AU - Aweeka, F. T.

PY - 1994

Y1 - 1994

N2 - The pharmacodynamic relationship between a range of foscarnet exposure measurements obtained from studying nine patients receiving ongoing maintenance therapy for cytomegalovirus retinitis and a range of efficacy values (days to retinitis progression) obtained by independent examination of serial retinal photographs from the same nine patients was analyzed. In the resulting proportional hazards models, the foscarnet area under the concentration-time curve approached statistical significance (P = 0.11) as a predictor of decreased risk of retinitis progression.

AB - The pharmacodynamic relationship between a range of foscarnet exposure measurements obtained from studying nine patients receiving ongoing maintenance therapy for cytomegalovirus retinitis and a range of efficacy values (days to retinitis progression) obtained by independent examination of serial retinal photographs from the same nine patients was analyzed. In the resulting proportional hazards models, the foscarnet area under the concentration-time curve approached statistical significance (P = 0.11) as a predictor of decreased risk of retinitis progression.

UR - https://www.scopus.com/pages/publications/0028334024

U2 - 10.1128/AAC.38.5.1190

DO - 10.1128/AAC.38.5.1190

M3 - Comment/debate

C2 - 8067763

AN - SCOPUS:0028334024

SN - 0066-4804

VL - 38

SP - 1190

EP - 1193

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 5

ER -

Pharmacodynamic relationship of pharmacokinetic parameters of maintenance doses of foscarnet and clinical outcome of cytomegalovirus retinitis

Abstract

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