Pharmacodynamic profile of mydriatic agents delivered by ocular piezo-ejection microdosing compared with conventional eyedropper

Tsontcho Ianchulev, Arturo Chayet, Malik Kahook, Mark Packer, Louis Pasquale, Robert N. Weinreb

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Aim: Eyedroppers deliver medication volumes exceeding conjunctival absorptive capacity, causing spillage and risking ocular/systemic complications. We evaluated piezoelectric microdosing. Results/methodology: Subjects (n = 102) received precision microdroplet delivery of phenylephrine (2.5%) and tropicamide (1.0%): 1 × 1.5 μl, 1 × 6 μl or 2 × 3 μl of each (randomized 1:1:1), into one eye. Contralateral eyes received eyedropper doses of both drugs. Outcomes were pupil dilation (0-60 min) and patient satisfaction. Six-microliter microdosing achieved comparable, and 2 × 3 μl met/exceeded dilation speed and magnitude versus eyedropper. Separately, participants preferred piezoelectric saline self-delivery to eyedroppers, reporting better head-positioning comfort, reduced tearing/overflow and increased likelihood of adhering to ocular medication regimens. Conclusion: Piezoelectric microdosing achieves comparable effects as eyedroppers delivering 4-17-fold larger doses. Microdosing may enhance patient adherence to ocular medication regimens while minimizing side effects.

Original languageEnglish
Pages (from-to)751-760
Number of pages10
JournalTherapeutic Delivery
Volume7
Issue number11
DOIs
StatePublished - Nov 2016
Externally publishedYes

Keywords

  • microdroplet ejection system
  • mydriasis
  • ocular drug delivery
  • ocular medication
  • piezoelectric
  • precision eye dosing

Fingerprint

Dive into the research topics of 'Pharmacodynamic profile of mydriatic agents delivered by ocular piezo-ejection microdosing compared with conventional eyedropper'. Together they form a unique fingerprint.

Cite this