Phagocytosis imprints heterogeneity in tissue-resident macrophages

Noelia A-Gonzalez, Juan A. Quintana, Susana García-Silva, Marina Mazariegos, Arturo González de la Aleja, José A. Nicolás-ávila, Wencke Walter, Jose M. Adrover, Georgiana Crainiciuc, Vijay K. Kuchroo, Carla V. Rothlin, Héctor Peinado, Antonio Castrillo, Mercedes Ricote, Andrés Hidalgo

Research output: Contribution to journalArticlepeer-review

157 Scopus citations

Abstract

Tissue-resident macrophages display varying phenotypic and functional properties that are largely specified by their local environment. One of these functions, phagocytosis, mediates the natural disposal of billions of cells, but its mechanisms and consequences within living tissues are poorly defined. Using a parabiosis-based strategy, we identified and isolated macrophages from multiple tissues as they phagocytosed blood-borne cellular material. Phagocytosis was circadianally regulated and mediated by distinct repertoires of receptors, opsonins, and transcription factors in macrophages from each tissue. Although the tissue of residence defined the core signature of macrophages, phagocytosis imprinted a distinct antiinflammatory profile. Phagocytic macrophages expressed CD206, displayed blunted expression of Il1b, and supported tissue homeostasis. Thus, phagocytosis is a source of macrophage heterogeneity that acts together with tissue-derived factors to preserve homeostasis.

Original languageEnglish
Pages (from-to)1281-1296
Number of pages16
JournalJournal of Experimental Medicine
Volume214
Issue number5
DOIs
StatePublished - 1 May 2017
Externally publishedYes

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