Abstract
This chapter discusses the background, prevention measures, diagnosis, treatment, and prognosis for phagocytic cell disorders. Phagocytic disorder is the result of inherited defects of the immune system. Genetic phagocytic disorders is divided into several groups such as defects of neutrophil differentiation (neutropenia), defects of motility, and defects of respiratory burst. The results in each case lead to recurrent and/or severe infections with fungi (e.g. Candida and Aspergillus spp) and/or bacteria (e.g. Staphylococcus aureus, Pseudomonas sp. and Nocardia sp.). Impaired phagocytic functions can also occur secondary to drug reactions, diabetes mellitus, metabolic storage diseases, malnutrition, immaturity, or burns. In addition, loss of neutrophils may be associated with autoimmunity, or other immune deficiency diseases. Genetic mutations responsible for phagocytic cell disorders are passed on from generation to generation in various inheritance patterns, or can occur spontaneously.
| Original language | English |
|---|---|
| Title of host publication | Allergy and Clinical Immunology |
| Publisher | wiley |
| Pages | 408-414 |
| Number of pages | 7 |
| ISBN (Electronic) | 9781118609125 |
| ISBN (Print) | 9781118609163 |
| DOIs | |
| State | Published - 1 Jan 2015 |
Keywords
- candida
- diabetes mellitus
- immune system
- motility
- neutropenia
- neutrophils
- phagocytic cell disorders
- pseudomonas sp.
- respiratory burst