TY - JOUR
T1 - PET/MR imaging of inflammation in atherosclerosis
AU - Senders, Max L.
AU - Calcagno, Claudia
AU - Tawakol, Ahmed
AU - Nahrendorf, Matthias
AU - Mulder, Willem J.M.
AU - Fayad, Zahi A.
N1 - Publisher Copyright:
© 2022, Springer Nature Limited.
PY - 2023/3
Y1 - 2023/3
N2 - Myocardial infarction, stroke, mental disorders, neurodegenerative processes, autoimmune diseases, cancer and the human immunodeficiency virus impact the haematopoietic system, which through immunity and inflammation may aggravate pre-existing atherosclerosis. The interplay between the haematopoietic system and its modulation of atherosclerosis has been studied by imaging the cardiovascular system and the activation of haematopoietic organs via scanners integrating positron emission tomography and resonance imaging (PET/MRI). In this Perspective, we review the applicability of integrated whole-body PET/MRI for the study of immune-mediated phenomena associated with haematopoietic activity and cardiovascular disease, and discuss the translational opportunities and challenges of the technology.
AB - Myocardial infarction, stroke, mental disorders, neurodegenerative processes, autoimmune diseases, cancer and the human immunodeficiency virus impact the haematopoietic system, which through immunity and inflammation may aggravate pre-existing atherosclerosis. The interplay between the haematopoietic system and its modulation of atherosclerosis has been studied by imaging the cardiovascular system and the activation of haematopoietic organs via scanners integrating positron emission tomography and resonance imaging (PET/MRI). In this Perspective, we review the applicability of integrated whole-body PET/MRI for the study of immune-mediated phenomena associated with haematopoietic activity and cardiovascular disease, and discuss the translational opportunities and challenges of the technology.
UR - https://www.scopus.com/pages/publications/85144050029
U2 - 10.1038/s41551-022-00970-7
DO - 10.1038/s41551-022-00970-7
M3 - Article
AN - SCOPUS:85144050029
SN - 2157-846X
VL - 7
SP - 202
EP - 220
JO - Nature Biomedical Engineering
JF - Nature Biomedical Engineering
IS - 3
ER -