PET Imaging of Microglia Activation and Infection in Neuropsychiatric Disorders with Potential Infectious Origin

Hans Christiaan Klein, Lot de Witte, Robert Bransfield, Peter Paul de Deyn

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations

Abstract

The central nervous system (CNS) is an immunoprivileged location for the possible sequestration of latent infections. The presence of pathogens may be involved in the etiology of neuropsychiatric diseases by inducing classical inflammatory responses, hypersensitivity, cellular toxicity, or direct alteration of cellular processes. Infection, persistence, and activation of microbes in the brain are not easy to assess in vivo, and the relation with clinical disease is very difficult to prove. An elegant way to determine an inflammatory response in the brain in vivo is by molecular imaging of microglia activation with [11C]PK11195 and other radiopharmaceuticals that target the translocator protein (TSPO). In this chapter, we summarize the neuroimaging studies that target the TSPO in patients with neuropsychiatric diseases, and we propose positron emission tomography (PET) imaging with radiopharmaceuticals that target the metabolism of infectious agents directly.

Original languageEnglish
Title of host publicationPET and SPECT in Neurology
PublisherSpringer International Publishing
Pages873-892
Number of pages20
ISBN (Electronic)9783030531683
ISBN (Print)9783030531676
DOIs
StatePublished - 20 Oct 2020

Keywords

  • Herpes simplex virus encephalitis
  • Microglia activation
  • Neuropsychiatric disease
  • Positron emission tomography imaging
  • West Nile virus

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