Perspectives de thérapie génique pour les sténoses artérielles

Translated title of the contribution: Perspectives of gene therapy for arterial stenosis

E. Reis, F. Mosimann, P. Aebischer

Research output: Contribution to journalArticlepeer-review

Abstract

Trauma to the arterial wall leads to growth of smooth muscle cells (SMC) and neointimal formation that is a central feature of restenosis following angioplasty, vascular bypass failure and transplant arteriosclerosis. Cenetic interventions affecting the cell cycle have been effective to limit SMC proliferation in vitro and in animal models. Strategies have included the use of antisense oligonucleotides to block protein synthesis, transduced genes to cause cytotoxicity and genetically injury. Clinical application of gene therapy in vascular diseases should follow the evolution of delivery systems that permit efficient insitu gene transfer.

Translated title of the contributionPerspectives of gene therapy for arterial stenosis
Original languageFrench
Pages (from-to)1591-1594
Number of pages4
JournalMedecine et Hygiene
Volume54
Issue number2129
StatePublished - 1996
Externally publishedYes

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