TY - JOUR
T1 - Personal care product use and urinary levels of phthalate metabolites in Mexican women
AU - Romero-Franco, Michelle
AU - Hernández-Ramírez, Raúl U.
AU - Calafat, Antonia M.
AU - Cebrián, Mariano E.
AU - Needham, Larry L.
AU - Teitelbaum, Susan
AU - Wolff, Mary S.
AU - López-Carrillo, Lizbeth
N1 - Funding Information:
Authors gratefully acknowledge B.Sc. Verónica López for the overall coordination of field work, and Manori Silva, Tao Jia, Ella Samandar and Jim Preau for their technical assistance in measuring the urinary concentrations of phthalate metabolites. The study was supported by CONACYT Fondo Sectorial de Investigación en Salud y Seguridad Social (FOSISS) 2005-C02-14373 , FOSISS 2009-01-111384 and SEP-CONACYT 2008-79912 . Michelle Romero-Franco is an Irving J. Selikoff International Scholar of the Mount Sinai School of Medicine. Her work was supported in part by Award Number D43TW000640 from the Fogarty International Center. The content is solely the responsibility of the authors and does not necessarily represent the official views of the Fogarty International Center or the National Institutes of Health. The findings expressed in this paper are the opinions of the authors and do not necessarily reflect the official opinion of the Centers for Disease Control and Prevention.
PY - 2011/7
Y1 - 2011/7
N2 - Sources of phthalates other than Polyvinyl chloride (PVC) related products are scarcely documented in Mexico. The objective of our study was to explore the association between urinary levels of nine phthalate metabolites and the use of personal care products. Subjects included 108 women who participated as controls in an ongoing population-based case-control study of environmental factors and genetic susceptibility to breast cancer in northern Mexico. Direct interviews were performed to inquire about sociodemographic characteristics, reproductive history, use of personal care products, and diet. Phthalate metabolites measured in urine by high performance liquid chromatography-isotope dilution tandem mass spectrometry were monoethyl phthalate (MEP), monobenzyl phthalate (MBzP), mono-n-butyl phthalate (MBP), mono-isobutyl phthalate (MiBP), mono-3-carboxypropyl phthalate (MCPP) as well as mono-2-ethylhexyl phthalate (MEHP), mono-2-ethyl-5-oxohexyl phthalate (MEOHP), mono-2-ethyl-5-hydroxyhexyl phthalate (MEHHP), mono-2-ethyl-5-carboxypentyl phthalate (MECPP) that are metabolites of di-ethylhexyl phthalate (DEHP). Detectable urinary concentrations of phthalate metabolites varied from 75% (MEHP) to 100% (MEP, MBP, MEOHP, MEHHP and MECPP). Medians of urinary concentrations of some phthalate metabolites were significantly higher among users of the following personal care products compared to nonusers: body lotion (MEHHP, MECPP and sum of DEHP metabolites (σDEHP)), deodorant (MEHP and σDEHP), perfume (MiBP), anti-aging facial cream (MEP, MBP and MCPP) and bottled water (MCPP, MEHHP and MEOHP). Urinary concentrations of MEP showed a positive relationship with the number of personal care products used. Our results suggest that the use of some personal care products contributes to phthalate body burden that deserves attention due to its potential health impact.
AB - Sources of phthalates other than Polyvinyl chloride (PVC) related products are scarcely documented in Mexico. The objective of our study was to explore the association between urinary levels of nine phthalate metabolites and the use of personal care products. Subjects included 108 women who participated as controls in an ongoing population-based case-control study of environmental factors and genetic susceptibility to breast cancer in northern Mexico. Direct interviews were performed to inquire about sociodemographic characteristics, reproductive history, use of personal care products, and diet. Phthalate metabolites measured in urine by high performance liquid chromatography-isotope dilution tandem mass spectrometry were monoethyl phthalate (MEP), monobenzyl phthalate (MBzP), mono-n-butyl phthalate (MBP), mono-isobutyl phthalate (MiBP), mono-3-carboxypropyl phthalate (MCPP) as well as mono-2-ethylhexyl phthalate (MEHP), mono-2-ethyl-5-oxohexyl phthalate (MEOHP), mono-2-ethyl-5-hydroxyhexyl phthalate (MEHHP), mono-2-ethyl-5-carboxypentyl phthalate (MECPP) that are metabolites of di-ethylhexyl phthalate (DEHP). Detectable urinary concentrations of phthalate metabolites varied from 75% (MEHP) to 100% (MEP, MBP, MEOHP, MEHHP and MECPP). Medians of urinary concentrations of some phthalate metabolites were significantly higher among users of the following personal care products compared to nonusers: body lotion (MEHHP, MECPP and sum of DEHP metabolites (σDEHP)), deodorant (MEHP and σDEHP), perfume (MiBP), anti-aging facial cream (MEP, MBP and MCPP) and bottled water (MCPP, MEHHP and MEOHP). Urinary concentrations of MEP showed a positive relationship with the number of personal care products used. Our results suggest that the use of some personal care products contributes to phthalate body burden that deserves attention due to its potential health impact.
KW - Mexican women
KW - Personal care products
KW - Phthalates
UR - https://www.scopus.com/pages/publications/79955606572
U2 - 10.1016/j.envint.2011.02.014
DO - 10.1016/j.envint.2011.02.014
M3 - Article
AN - SCOPUS:79955606572
SN - 0160-4120
VL - 37
SP - 867
EP - 871
JO - Environment international
JF - Environment international
IS - 5
ER -