Persisting lymphopenia and dimethyl fumarate: A clinical commentary

Lara Diem, Andrew Chan

Research output: Contribution to journalArticlepeer-review


Severe prolonged lymphopenia as rare side-effect of dimethyl fumarate is mostly reversible. Caldito et al. report a case of persistent severe lymphopenia over 5 years after discontinuation of dimethyl fumarate. We discuss several clinical implications. Safe withdrawal of disease modifying therapies in terms of reoccurrence of disease activity and drug related adverse events need further attention as our treatment armamentarium continues to grow.

Original languageEnglish
Pages (from-to)1309-1310
Number of pages2
JournalMultiple Sclerosis Journal
Issue number8
StatePublished - Jul 2021
Externally publishedYes


  • Lymphopenia
  • case report
  • dimethyl fumarate
  • disease modifying therapies
  • safety
  • side effect


Dive into the research topics of 'Persisting lymphopenia and dimethyl fumarate: A clinical commentary'. Together they form a unique fingerprint.

Cite this