TY - JOUR
T1 - Persistent stimulatory effect of glucagon on glucose production despite downregulation
AU - Bloomgarden, Z. T.
AU - Liljenquist, J. E.
AU - Cherrington, A. D.
AU - Rabinowitz, D.
PY - 1978/11
Y1 - 1978/11
N2 - The rise and subsequent return to basal of glucose production (Ra) during a constant glucagon infusion ("downregulation") has suggested to some workers that glucagon's effects are evanescent. To examine whether glucagon displays persistent biological activity even after downregulation, 6 healthy males received an 8 hour infusion of somatostatin and glucagon, with 3H-3-glucose to measure glucose turnover. Ra rose from 2.8 ± 0.3 to 4.2 ± 0.3 mg/kg-min at 90 minutes, returned to basal levels at 150 minutes, and remained at this level for the ensuing 330 minutes. Six additional subjects received an 8 hour somatostatin infusion, with glucagon administered concomitantly for the first 5 hours. Glucagon withdrawal at 5 hours produced an immediate decline in Ra from 1.8 ± 0.2 to 0.9 ± 0.2 mg/kg.min. Thus, even after downregulation the maintenance of basal Ra is dependent on circulating glucagon. and; 1978 BY THE ENDOCRINE SOCIETY.
AB - The rise and subsequent return to basal of glucose production (Ra) during a constant glucagon infusion ("downregulation") has suggested to some workers that glucagon's effects are evanescent. To examine whether glucagon displays persistent biological activity even after downregulation, 6 healthy males received an 8 hour infusion of somatostatin and glucagon, with 3H-3-glucose to measure glucose turnover. Ra rose from 2.8 ± 0.3 to 4.2 ± 0.3 mg/kg-min at 90 minutes, returned to basal levels at 150 minutes, and remained at this level for the ensuing 330 minutes. Six additional subjects received an 8 hour somatostatin infusion, with glucagon administered concomitantly for the first 5 hours. Glucagon withdrawal at 5 hours produced an immediate decline in Ra from 1.8 ± 0.2 to 0.9 ± 0.2 mg/kg.min. Thus, even after downregulation the maintenance of basal Ra is dependent on circulating glucagon. and; 1978 BY THE ENDOCRINE SOCIETY.
UR - http://www.scopus.com/inward/record.url?scp=0018129784&partnerID=8YFLogxK
U2 - 10.1210/jcem-47-5-1152
DO - 10.1210/jcem-47-5-1152
M3 - Article
C2 - 45472
AN - SCOPUS:0018129784
SN - 0021-972X
VL - 47
SP - 1152
EP - 1155
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
IS - 5
ER -