Persistent Expression of Recipient-type ABH Antigen after ABO-incompatible Allogeneic Hematopoietic Stem Cell Transplantation

Yukiko Misaki; Shinichi Kako; Shunto Kawamura; Junko Takeshita; Nozomu Yoshino; Kazuki Yoshimura; Ayumi Gomyo; Yu Akahoshi; Masaharu Tamaki; Machiko Kusuda; Kazuaki Kameda; Hidenori Wada; Koji Kawamura; Miki Sato; Kiriko Terasako-Saito; Shun Ichi Kimura; Hideki Nakasone; Koji Kishino; Kazuo Muroi; Yoshinobu Kanda

doi:10.2169/internalmedicine.8315-21

Persistent Expression of Recipient-type ABH Antigen after ABO-incompatible Allogeneic Hematopoietic Stem Cell Transplantation

Yukiko Misaki
, Shinichi Kako
, Shunto Kawamura
, Junko Takeshita
, Nozomu Yoshino
, Kazuki Yoshimura
, Ayumi Gomyo
, Yu Akahoshi
, Masaharu Tamaki
, Machiko Kusuda
, Kazuaki Kameda
, Hidenori Wada
, Koji Kawamura
, Miki Sato
, Kiriko Terasako-Saito
, Shun Ichi Kimura
, Hideki Nakasone
, Koji Kishino
, Kazuo Muroi
, Yoshinobu Kanda

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

In general, the recipient’s ABO blood type changes to the donor’s ABO blood type after ABO-incompatible allogeneic hematopoietic stem cell transplantation (HSCT). However, we experienced a 26-year-old male with acute myelogenous leukemia (AML) who underwent ABO-incompatible HSCT twice and persistently showed his original blood type even after demonstrating complete donor-type chimerism. Based on the results of various examinations, we considered that the antigen of the recipient’s original blood type persistently synthesized in the recipient’s non-hematopoietic organs was secreted and adsorbed on the surface of donor-derived RBCs. We should therefore perform detailed examinations to determine the precise blood type after ABO-incompatible HSCT.

Original language	English
Pages (from-to)	1887-1890
Number of pages	4
Journal	Internal Medicine
Volume	61
Issue number	12
DOIs	https://doi.org/10.2169/internalmedicine.8315-21
State	Published - 2022
Externally published	Yes

Keywords

ABO blood group antigen
ABO-incompatibility
allogeneic HSCT
blood type
transfusion

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10.2169/internalmedicine.8315-21

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Misaki, Y., Kako, S., Kawamura, S., Takeshita, J., Yoshino, N., Yoshimura, K., Gomyo, A., Akahoshi, Y., Tamaki, M., Kusuda, M., Kameda, K., Wada, H., Kawamura, K., Sato, M., Terasako-Saito, K., Kimura, S. I., Nakasone, H., Kishino, K., Muroi, K., & Kanda, Y. (2022). Persistent Expression of Recipient-type ABH Antigen after ABO-incompatible Allogeneic Hematopoietic Stem Cell Transplantation. Internal Medicine, 61(12), 1887-1890. https://doi.org/10.2169/internalmedicine.8315-21

@article{6757b533eab74b63992d48d980ea30b9,

title = "Persistent Expression of Recipient-type ABH Antigen after ABO-incompatible Allogeneic Hematopoietic Stem Cell Transplantation",

abstract = "In general, the recipient{\textquoteright}s ABO blood type changes to the donor{\textquoteright}s ABO blood type after ABO-incompatible allogeneic hematopoietic stem cell transplantation (HSCT). However, we experienced a 26-year-old male with acute myelogenous leukemia (AML) who underwent ABO-incompatible HSCT twice and persistently showed his original blood type even after demonstrating complete donor-type chimerism. Based on the results of various examinations, we considered that the antigen of the recipient{\textquoteright}s original blood type persistently synthesized in the recipient{\textquoteright}s non-hematopoietic organs was secreted and adsorbed on the surface of donor-derived RBCs. We should therefore perform detailed examinations to determine the precise blood type after ABO-incompatible HSCT.",

keywords = "ABO blood group antigen, ABO-incompatibility, allogeneic HSCT, blood type, transfusion",

author = "Yukiko Misaki and Shinichi Kako and Shunto Kawamura and Junko Takeshita and Nozomu Yoshino and Kazuki Yoshimura and Ayumi Gomyo and Yu Akahoshi and Masaharu Tamaki and Machiko Kusuda and Kazuaki Kameda and Hidenori Wada and Koji Kawamura and Miki Sato and Kiriko Terasako-Saito and Kimura, \{Shun Ichi\} and Hideki Nakasone and Koji Kishino and Kazuo Muroi and Yoshinobu Kanda",

year = "2022",

doi = "10.2169/internalmedicine.8315-21",

language = "English",

volume = "61",

pages = "1887--1890",

journal = "Internal Medicine",

issn = "0918-2918",

publisher = "Japanese Society of Internal Medicine",

number = "12",

}

Misaki, Y, Kako, S, Kawamura, S, Takeshita, J, Yoshino, N, Yoshimura, K, Gomyo, A, Akahoshi, Y, Tamaki, M, Kusuda, M, Kameda, K, Wada, H, Kawamura, K, Sato, M, Terasako-Saito, K, Kimura, SI, Nakasone, H, Kishino, K, Muroi, K & Kanda, Y 2022, 'Persistent Expression of Recipient-type ABH Antigen after ABO-incompatible Allogeneic Hematopoietic Stem Cell Transplantation', Internal Medicine, vol. 61, no. 12, pp. 1887-1890. https://doi.org/10.2169/internalmedicine.8315-21

TY - JOUR

T1 - Persistent Expression of Recipient-type ABH Antigen after ABO-incompatible Allogeneic Hematopoietic Stem Cell Transplantation

AU - Misaki, Yukiko

AU - Kako, Shinichi

AU - Kawamura, Shunto

AU - Takeshita, Junko

AU - Yoshino, Nozomu

AU - Yoshimura, Kazuki

AU - Gomyo, Ayumi

AU - Akahoshi, Yu

AU - Tamaki, Masaharu

AU - Kusuda, Machiko

AU - Kameda, Kazuaki

AU - Wada, Hidenori

AU - Kawamura, Koji

AU - Sato, Miki

AU - Terasako-Saito, Kiriko

AU - Kimura, Shun Ichi

AU - Nakasone, Hideki

AU - Kishino, Koji

AU - Muroi, Kazuo

AU - Kanda, Yoshinobu

PY - 2022

Y1 - 2022

N2 - In general, the recipient’s ABO blood type changes to the donor’s ABO blood type after ABO-incompatible allogeneic hematopoietic stem cell transplantation (HSCT). However, we experienced a 26-year-old male with acute myelogenous leukemia (AML) who underwent ABO-incompatible HSCT twice and persistently showed his original blood type even after demonstrating complete donor-type chimerism. Based on the results of various examinations, we considered that the antigen of the recipient’s original blood type persistently synthesized in the recipient’s non-hematopoietic organs was secreted and adsorbed on the surface of donor-derived RBCs. We should therefore perform detailed examinations to determine the precise blood type after ABO-incompatible HSCT.

AB - In general, the recipient’s ABO blood type changes to the donor’s ABO blood type after ABO-incompatible allogeneic hematopoietic stem cell transplantation (HSCT). However, we experienced a 26-year-old male with acute myelogenous leukemia (AML) who underwent ABO-incompatible HSCT twice and persistently showed his original blood type even after demonstrating complete donor-type chimerism. Based on the results of various examinations, we considered that the antigen of the recipient’s original blood type persistently synthesized in the recipient’s non-hematopoietic organs was secreted and adsorbed on the surface of donor-derived RBCs. We should therefore perform detailed examinations to determine the precise blood type after ABO-incompatible HSCT.

KW - ABO blood group antigen

KW - ABO-incompatibility

KW - allogeneic HSCT

KW - blood type

KW - transfusion

UR - https://www.scopus.com/pages/publications/85132017367

U2 - 10.2169/internalmedicine.8315-21

DO - 10.2169/internalmedicine.8315-21

M3 - Article

C2 - 34803100

AN - SCOPUS:85132017367

SN - 0918-2918

VL - 61

SP - 1887

EP - 1890

JO - Internal Medicine

JF - Internal Medicine

IS - 12

ER -

Persistent Expression of Recipient-type ABH Antigen after ABO-incompatible Allogeneic Hematopoietic Stem Cell Transplantation

Abstract

Keywords

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