Persistence of Phosphoglucomutase (PGM) Polymorphism in Long-Term Lymphoid Lines (34557)

Long-term lymphoid lines are useful in studying the relationship of an individual's genotype in vivo and in vitro. The persistence of the PGM₁ phenotype in these established lines serves as a consistent, reliable genetic marker which can be used in a variety of studies and be related directly back to the cell line donor. This experimental advantage was heretofore not available in established heteroploid monolayer lines, or in diploid fibroblasts, which are not capable of continuous vigorous growth beyond a finite number of generations.